Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & ISI's SCI  
Users online: 23292  
Home | Subscribe | Feedback | Login 
About Latest Articles Back-Issues Articlesmenu-bullet Search Instructions Online Submission Subscribe Etcetera Contact
 :: Next article
 :: Previous article 
 :: Table of Contents
 ::  Similar in PUBMED
 ::  Search Pubmed for
 ::  Search in Google Scholar for
 ::Related articles
 ::  Article in PDF (11 KB)
 ::  Citation Manager
 ::  Access Statistics
 ::  Reader Comments
 ::  Email Alert *
 ::  Add to My List *
* Registration required (free) 

  IN THIS Article
 ::  Abstract
 ::  Introduction
 ::  Case report
 ::  Discussion
 ::  References
 ::  Article Figures

 Article Access Statistics
    PDF Downloaded119    
    Comments [Add]    
    Cited by others 8    

Recommend this journal


Year : 1996  |  Volume : 42  |  Issue : 4  |  Page : 125-6

Pleomorphic adenoma of skin (chondroid syringoma) involving the eyelid.

Department of Pathology and Institute of Ophthalmology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh.

Correspondence Address:
N N Tyagi
Department of Pathology and Institute of Ophthalmology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh.

Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 0009715316

Rights and PermissionsRights and Permissions

 :: Abstract 

Lid tumours are fairly common. However, pleomorphic adenoma (chondroid syringoma) is quite rare. In a series of 207 eyelid tumours and tumour like lesions, pleomorphic adenoma was observed in a male aged 41 years; its incidence being 0.48%.

Keywords: Adenoma, Pleomorphic, pathology,surgery,Adult, Case Report, Eyelid Neoplasms, pathology,surgery,Human, Male, Sweat Gland Neoplasms, pathology,surgery,

How to cite this article:
Tyagi N N, Abdi U U, Tyagi S P, Maheshwari V V, Gogi R R. Pleomorphic adenoma of skin (chondroid syringoma) involving the eyelid. J Postgrad Med 1996;42:125

How to cite this URL:
Tyagi N N, Abdi U U, Tyagi S P, Maheshwari V V, Gogi R R. Pleomorphic adenoma of skin (chondroid syringoma) involving the eyelid. J Postgrad Med [serial online] 1996 [cited 2023 Sep 23];42:125. Available from:

  ::   Introduction Top

Pleomorphic adenoma or chondroid syringoma of the skin involving the eyelid is a rare tumour[1]. Occasional case reports have been published in Indian literature[2],[3]. This tumour can have either ecerine or apocrine differentiation. The authors have come across a single case of chondroid syringoma out of a series of 207 cases of tumours and tumour like conditions of the eyelid. The rarity of the lesion has promoted them to publish this case.

  ::   Case report Top

M. A., a male aged 41 years presented with the complaint of nodular mass on the left upper eyelid for the last year. The growth was 5 mm in diameter, firm in consistency. The surface was smooth and there was no induration, ulceration or discharge. The mass was fixed to the underlying tarsus. There was no preauricular or submandibular lymphadenopathy. Clinically, the case was diagnosed as a case of Meibornian gland carcinoma of the left upper lid. The mass was excised and sent for histo-pathologic examination.

The mass removed was a small non-hairy nodule of 5 mm size with smooth surface and surrounded by a tag of the skin. Consistency was firm. There was no discharge. Cut surface was white and homogenous.

Morphologically the neoplasm was characterised by the presence of tubular glands of variable size, lying in a lightly bluish stained mucoid myxomatous stroma [Figure - 1]. The mucoid stroma gave positive reaction with Alcian blue and stained metachromatically with toluidine blue. The glandular epithelial lining was double layered - the luminal layer was cuboidal and the outer spindle cell type or of vaueolated cells representing the myciepithelial component. Some of the tubular lumina contained small amount of amorphous eosinophilic diastase resistant material. In some areas, the tumour cells were spindle cell type suggesting a mesenchymal element probably derived from the myoepithelial cells. Mitoses as well as necrosis were not seen. A morphologic diagnosis of plemorphic adenoma or mixed tumour of the sweat gland involving the left upper lid was made.

  ::   Discussion Top

Sweat gland tumours are usually solitary and almost invariably benign. They appear as hard circumscribed nodule in the skin, slowly growing and asymptomatic, but may assume a considerable size with polypoid term. They are frequently encapsulated[4]. Pleomorphic adenoma of the eyelid is still very rare as we have come across a single case out of a series of 207 cases of tumours and tumour like lesions of the eyelid, its incidence being 0.48%.

Hirsch and Helwig[5] introduced the term of chondroid syringoma in place of pleomorphic adenoma or mixed tumour of the skin, as the tumour is epithelial in nature (arising from the sweat gland elements) with secondary changes in the stroma (cartilage - like substance). These tumours usually occur as asymptomatic, firm well-circumscribed nodules of the size between 0.3 mm to 0.5 mm in diameter 5 as was also noticed in the present case.

Headington [6] has described 2 types of chondroid syringomas depending upon the morphological picture. The present case was chondroid syringoma with tubular, branching lumina. In general, the tubular structures are highly suggestive of eccrine differentiation[5]. The other variety is chondroid syringoma with small, tubular lumina in which glands are lined by single layer of flat epithelial cells. The tumour can differentiate either to eccrine or apocrine elements and very rarely it can undergo malignant change with widespread metastases[7].

 :: References Top

1. Zimmerman LE, Sobin LK. Histological typing of tumour of eye and its adnexa. International Histological Classification of Tumour No.24. Geneva: World Health Organisation; 1980.  Back to cited text no. 1    
2.Kapoor VK, Kumar S, Singh MK, Chattopadhyay TK. Pleomorphic adenoma of skin (Chondroid Syringoma). Indian J Pathol Microbiol 1986; 29:309-311.  Back to cited text no. 2    
3.Vaishnav VP, Dharkar DD. Adnexal tumours of the skin. Indian J Pathol Bacteriol 1974; 17:33-38.  Back to cited text no. 3    
4.Duke Elder S, Mac Faul PA. The ocular Adnexa. Diseases of the Eyelids. In Duke Elder's System of Ophthalmology Vol. 13, London: Henry Kimpton; 1974, pp 461-462.  Back to cited text no. 4    
5.Hirsch P, Helwig EB. Chondroid Syringoma. Mixed tumour of the skin, salivary gland type. Arch Dermatol 1961; 84:835-847.  Back to cited text no. 5    
6.Headington JI. Mixed tumours of the skin: Eccrine and apocrine types. Arch Dermatol 1961; 84:989-996.  Back to cited text no. 6    
7.Shvili D, Rothem A. Fulminant metastasizing chondroid syringoma of the skin. Am J Dermatopathol 1986; 8:3215.   Back to cited text no. 7    


[Figure - 1]

This article has been cited by
1 Pleomorphic adenoma with extensive myoepithelial component (myoepithelioma) of the lower eyelid
Huerva V, Sanchez MC, Egido RM, et al.
2 A rare case of atypical chondroid syringoma of the lower eyelid and review of the literature
Gunduz K, Demirel S, Heper AO, et al.
SURVEY OF OPHTHALMOLOGY. 2006; 51 (3): 280-285
3 Pathology of the eyelid in elderly patients
Thomas L, Dalle S
4 The chondroid syringoma: report of a case arising from the external auditory canal
Kaushik V, Bhalla RK, Nicholson C, de Carpentier JP
5 Cutaneous benign mixed tumor (Chondroid syringoma) of the eyelid: Clinical presentation and management
Mandeville JTH, Roh JH, Woog JJ, et al.
6 Subcutaneous pleomorphic adenomas in two different areas of the face
Tsukuno M, Nakamura A, Takai S, et al.
7 Chondroid syringomas of the eyelid: two cases
Mencia-Gutierrez E, Bonales-Daimiel JA, Gutierrez-Diaz E, et al.
8 Benign chondroid syringoma: Report of a case clinically mimicking a malignant neoplasm
Sheikh SS, Pennanen M, Montgomery E
JOURNAL OF SURGICAL ONCOLOGY. 2000; 73 (4): 228-230


Print this article  Email this article
Previous article Next article
Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow