Journal of Postgraduate Medicine
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Year : 2000  |  Volume : 46  |  Issue : 4  |  Page : 293-6

Acute renal allograft rejection: progress in understanding cellular and molecular mechanisms.

Department of Pathology, Seth G. S. Medical College & K. E. M. Hospital, Parel - 400 012, Mumbai, India. , India

Correspondence Address:
S A Divate
Department of Pathology, Seth G. S. Medical College & K. E. M. Hospital, Parel - 400 012, Mumbai, India.
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Source of Support: None, Conflict of Interest: None

PMID: 11435662

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The application of molecular biology tools to investigate the molecular basis of acute allograft rejection has unravelled many complex mechanisms and improved immunosuppressive therapies leading to significant improvements in graft survival. The "indirect" pathway of antigen presentation has emerged as more important, than the traditional "direct" pathway, for allorecognition by T cells. The recognition that CD28 costimulation is essential for allorecognition has provided novel targets for immunotherapy such as CTLA-Immunoglobulin. Understanding the role of Th1 and Th2 subsets of T helper cells, the cytokine network and cell adhesion molecules in the mediation or prevention of graft rejection has opened new avenues for research into therapeutic modalities. The ideal objective would be to identify the mechanisms of graft destruction and design specific inhibitors. This review highlights recent advances in the understanding of acute renal allograft rejection which may have future potential for rational design of new immunosuppressive strategies.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow