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| ORIGINAL ARTICLE |
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| Year : 2001 | Volume
: 47
| Issue : 3 | Page : 165-70 |
Hypertrophic cardiomyopathy: an autopsy analysis of 14 cases.
RS Phadke, P Vaideeswar, B Mittal, J Deshpande
Department of Pathology, Seth G. S. Medical College and K. E. M. Hospital, Mumbai, India. , India
Correspondence Address:
R S Phadke
Department of Pathology, Seth G. S. Medical College and K. E. M. Hospital, Mumbai, India.
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 11832616 
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is one of the less common forms of primary cardiomyopathies. There is little data available on HCM in Indian literature. AIMS: To assess the incidence and analyse the clinicopathological features of HCM. SETTINGS: Analysis of data of 15 years from a tertiary care centre. METHODS AND MATERIAL: The clinical and pathological data in fourteen cases of HCM with respect to their gross and microscopic features and clinical presentation were reviewed. RESULTS: Incidence of HCM amongst the autopsied primary cardiomyopathies (N = 101) was 13.9% (n=14). Males were affected more. Common presenting symptoms were exertional dyspnoea, angina and palpitations. Concentric and asymmetric hypertrophy was equally seen. Obliterative small vessel disease was noted in 50% of the cases. Although significant myofibre disarray (>5%) was seen in all fourteen cases, it could be demonstrated in only 40- 50% of an average of twenty sections studied. Type IA myofibre disarray was the commonest. Six of the fourteen patients died suddenly. Cardiac failure was the commonest cause of death. CONCLUSIONS: Myofibre disarray is a highly sensitive and specific marker for HCM only when considered in a quantitative rather than a qualitative fashion. In this context, the rationale for performing endomyocardial biopsy is to rule out mimics of HCM.
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