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Year : 2002  |  Volume : 48  |  Issue : 3  |  Page : 197-8

Concomitant acral necrosis and haemolytic uraemic syndrome following ingestion of quinine.

Department of Internal Medicine, University of Iowa Hospital, Iowa City, Iowa 52242, USA. , USA

Correspondence Address:
N Agarwal
Department of Internal Medicine, University of Iowa Hospital, Iowa City, Iowa 52242, USA.
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Source of Support: None, Conflict of Interest: None

PMID: 12432194

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Thrombotic microangiopathy, which broadly includes thrombotic thrombocytopaenic purpura (TTP) and haemolytic uraemic syndrome (HUS), is a multisystemic disorder that is characterised by thrombocytopaenia, microangiopathic haemolytic anemia and ischaemic manifestations, resulting from platelet agglutination in the arterial microvasculature. Acral necrosis (distal necrosis of fingers and toes) occurs usually as a sequel to severe Raynaud's phenomenon, a vasculospastic disorder frequently related to endothelial cell dysfunction. We report a case of quinine induced TTP-HUS and acral necrosis, two distinct clinical abnormalities which have not yet been reported together in association with quinine. Both of these conditions in this case resolved promptly to treatment with corticosteroids.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow