Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & ISI's SCI  
Users online: 1767  
Home | Subscribe | Feedback | Login 
About Latest Articles Back-Issues Articlesmenu-bullet Search Instructions Online Submission Subscribe Etcetera Contact
 :: Next article
 :: Previous article 
 :: Table of Contents
 ::  Similar in PUBMED
 ::  Search Pubmed for
 ::  Search in Google Scholar for
 ::Related articles
 ::  Article in PDF (354 KB)
 ::  Citation Manager
 ::  Access Statistics
 ::  Reader Comments
 ::  Email Alert *
 ::  Add to My List *
* Registration required (free) 

  IN THIS Article
 ::  Abstract
 ::  Case history
 ::  Discussion
 ::  References
 ::  Article Figures

 Article Access Statistics
    PDF Downloaded250    
    Comments [Add]    
    Cited by others 10    

Recommend this journal


Year : 2002  |  Volume : 48  |  Issue : 4  |  Page : 283-4

Orofacial pain and numb chin syndrome as the presenting symptoms of a metastatic prostate cancer.

Department of Family Medicine, Sackler School of Medicine, Tel Aviv University, Israel. , Israel

Correspondence Address:
A Gaver
Department of Family Medicine, Sackler School of Medicine, Tel Aviv University, Israel.
Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 12571384

Rights and PermissionsRights and Permissions

 :: Abstract 

We describe a patient with orofacial pain as the presenting symptom caused by a mandibular metastasis from a previously undiagnosed cancer of the prostate. This possibility should be considered in the differential diagnosis of male patients presenting with orofacial pain.

Keywords: Adenocarcinoma, secondary,Aged, Case Report, Facial Pain, etiology,Human, Male, Mandibular Neoplasms, secondary,Prostatic Neoplasms, pathology,

How to cite this article:
Gaver A, Polliack G, Pilo R, Hertz M, Kitai E. Orofacial pain and numb chin syndrome as the presenting symptoms of a metastatic prostate cancer. J Postgrad Med 2002;48:283

How to cite this URL:
Gaver A, Polliack G, Pilo R, Hertz M, Kitai E. Orofacial pain and numb chin syndrome as the presenting symptoms of a metastatic prostate cancer. J Postgrad Med [serial online] 2002 [cited 2023 Jun 1];48:283. Available from:

Temporomandibular disorders causing orofacial pain are common in primary care settings.[1] Most of these conditions are of a chronic and benign nature. Orofacial pain may, however, be caused by a primary or secondary malignant process in the bone. The most common malignant bone tumor is metastatic carcinoma and tumors arising in the breast, prostate, thyroid, lung, and kidney have a special propensity to spread to bone. Yet metastases to the jaws are rare: less than 1% of all tumors metastatise to the maxillofacial area.[2]

We describe a patient who presented with a rare manifestation of the most common cancer in males: a metastasis to the mandible manifested by orofacial pain as the presenting symptom of a previously undiagnosed cancer of the prostate.

  ::   Case history Top

A 73-year-old man was seen by his family physician for the complaint of pain anterior to his right ear. He also had a history of hypertension, dyslipidaemia and cholelithiasis. The pain was relieved by non-steroidal anti-inflammatory drugs.

On a repeat visit one month later he again complained of pain in his right lower jaw and lower teeth, as well as of numbness of the chin and of the right side of his lower lip. He also mentioned constipation as an after complaint this time. His dental examination was normal.

He was referred to a neurologist and to a maxillofacial surgeon. Physical examination and panoramic radiogram of the teeth were normal. A panoramic radiogram of the mandible and a computerised tomogram of the oral region showed lytic lesions of the ascending ramus of the right mandible with partial destruction of the cortex, involving the mandibular angle and the posterior segment of the bone, the foramen and the mandibular canal [Figures:1] to [Figure - 3]. A blood test revealed elevated levels of Prostate Specific Antigen (PSA, 68 ng/ml; normal 0-4 ng/ml). On biopsy of the lesion metastatic carcinoma was found. Immunohistochemical staining for PSA indicated that the metastasis originated in the prostate.

Computerised tomogram of the abdomen and pelvis showed a soft tissue mass partially destroying the sacrum. At the level of the pubic bones an enlarged prostate was demonstrated, compressing both bladder and rectum. This was apparently the cause of the recent constipation. Computerised tomogram of the chest was normal.

A transrectal biopsy of the prostate confirmed the presence of adenocarcinoma of the prostate. A bone scan showed no other metastases than the ones reported. The patient was referred to an oncologist, and treatment was started with flutamide and goselerin.

  ::   Discussion Top

Temporomandibular disorders are common in clinical practice. They present with three cardinal features, orofacial pain is one of them; the other two being joint noises and restricted jaw function.[1] The symptoms most often encountered are myofascial pain and dysfunction, due to habits of clenching or bruxism. These habits are sometimes related to stress or anxiety. Other causes are internal derangement, (mechanical interference due to an abnormal position of the articular disc) or osteoarthritis of the temporomandibular joint.[1]

Metastatic tumours of the jaws are rare: less than 1% of all tumours metastasise to the maxillofacial area. Reports of these rare cases have been mainly published in oral surgery journals[3],[4],[5],[6] or in the oncological literature.[7],[8],[9] Lately, a similar case report has been published in Urology.[10]

General physicians, who, even in the internet access era, read mainly general medicine journals, may not be familiar with these reports. The patient reported here with orofacial pain proved to have a metastasis to the mandible from a previously undiagnosed prostate carcinoma. We found reports of only seven patients who had jaw symptoms as the presenting feature of a previously undiagnosed malignant tumor.[4],[5],[6],[10]

In our case, the patient also presented with another rare symptom: mental nerve neuropathy, causing unilateral numbness of the chin and lower lip.

Sensory neuropathy confined to the chin and lower lip indicates a lesion involving only the mental or inferior alveolar branches of the mandibular division of the trigeminal nerve.[7] Though rare, it is considered an ominous sign for relapsed or progressive malignant skeletal disease. The pathogenesis in most cases, as it was probably in our patient, is a bone metastasis directly affecting the nerve branch. Lossos and Siegal[11] found a metastatic aetiology in 89% of their patients with the numb chin syndrome. Therefore, mental nerve neuropathy combined with orofacial pain, is an alarming combination that should make clinicians suspect a jaw metastasis.

Family physicians, who frequently advice patients with complaints of orofacial pain, should bear in mind, that whereas most of these symptoms are of a chronic and benign nature, metastasis to the mandible from a malignant tumour should be included in the differential diagnosis.

 :: References Top

1.Dimitroulis G. Temporomandibular Disorders: A Clinical Update. BMJ 1998; 317: 190-194  Back to cited text no. 1    
2.Thatcher SL, Dye CG, Grau MJ, Neale HW. Carcinoma of the prostate metastatic to the mandibular condyle mimicking a parotid tumor. J Oral Maxillofac Surg 1986; 44: 394-397  Back to cited text no. 2    
3.Sanchez Aniceto G, Garcia Penin A, de la Mata Pages R, Montalvo moreno JJ. Tumors metastatic to the mandible: analysis of nine cases and review of the literature. J Oral Maxillofac Surg 1990; 48: 246-251  Back to cited text no. 3    
4.Glaser C, Lang S, Pruckmayer M, Millesi W, Rasse M, Marosi C, Leitha T. Clinical manifestations and diagnostic approach to metastatic cancer of the mandible. Int J Oral Maxillofac Surg 1997; 26: 365-368.  Back to cited text no. 4    
5.Galen DM. Mandibular metastasis of endometrial carcinoma diagnosed via a dental radiograph. J Am Dent Assoc 1998; 129: 1595-1598.  Back to cited text no. 5    
6.Itro A, Carotenuto A, Aquino S, Vestuto A. Metastases to the human mandible. Minerva Stomatol 1999; 48: 543-552  Back to cited text no. 6    
7.Burt RK, Sharfman WH, Karp BI, Wilson WH. Mental neuropathy (Numb Chin Syndrome). Cancer 1992; 70: 877-881.  Back to cited text no. 7    
8.Hirshberg A, Buchner A. Metastatic tumours to the oral region. An overview. Eur J Cancer B Oral Oncol 1995; 31B: 355-360  Back to cited text no. 8    
9.Pruckmayer M, Glaser C, Marosi C, Leitha T. Mandibular pain as the leading clinical symptom for metastatic disease: nine cases and review of the literature. Ann Oncol 1998; 9: 559-564.  Back to cited text no. 9    
10.Halachmi S, Madeb R, Madjar S, Wald M, River Y, Nativ O. Numb chin syndrome as the presenting symptom of metastatic prostate carcinoma. Urology 2000; 55: 286i-286iii   Back to cited text no. 10    
11.Lossos A, Siegal T. Numb chin syndrome in cancer patients: etiology, response to treatment, and prognostic significance. Neurology 1992; 42: 1181-1184.  Back to cited text no. 11    


[Figure - 1], [Figure - 2], [Figure - 3]

This article has been cited by
1 Numb chin syndrome: An ominous clinical sign
Ryba, F., Rice, S., Hutchison, I.L.
British Dental Journal. 2010; 208(7): 283-285
2 Numb chin syndrome: A case series and discussion
Divya, K.S., Moran, N.A., Atkin, P.A.
British Dental Journal. 2010; 208(4): 157-160
3 Numb chin syndrome: A difficult topographic diagnosis | [Neuropatía mentoniana: Un difícil diagnóstico topográfico]
Moreno-Izco, F., Ateka-Barrutia, O., Moreno-Izco, L., Ruiz-del Barrio, I., Gastón-Zubimendi, I., Moreno-Izco, I.
Revista de Neurologia. 2009; 48(10): 556-558
4 Metastatic prostate carcinoma presenting as numb chin syndrome in elderly people
Requena A, Riera-Mestre A, Formiga F, et al.
5 Mentonian hypoesthesis in a patient who smokes
Cairo FJM, Palacios MJS, Murcia JVF
REVISTA CLINICA ESPANOLA. 2008; 208(4): 205-205
6 Mental nerve neuropathy: patient characteristics and neurosensory changes
Kalladka M, Proter N, Benoliel R, et al.
7 Mental neuropathy as a manifestation associated with malignant processes: Its significance in relation to patient survival
Sanchis JM, Bagan JV, Murillo J, et al.
8 Mental neuropathy as initial sympton of metastatic gastric carcinoma
Atienza MR, Varela JM
NEUROLOGIA. 2008; 23(1): 71-72
9 Numb chin syndrome: a nonmetastatic neurological manifestation of malignancy
Smith, S.F., Blackman, G., Hopper, C.
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 2008; 105(3): e53-e56
10 Numb chin syndrome: The presenting symptom of a metastatic prostate carcinoma
Viganò, P., Picozzi, S.C.M., Giuberti, A., Casu, M., Manganini, V., Mazza, L., Strada, G.R.
Archivio Italiano di Urologia e Andrologia. 2007; 79(4): 155-157


Print this article  Email this article
Previous article Next article
Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow