Journal of Postgraduate Medicine
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Year : 2004  |  Volume : 50  |  Issue : 1  |  Page : 60-61

Unusual haematological alterations in rheumatoid arthritis

1 Department of Medicine, Government Medical College & Hospital, Sector 32, Chandigarh, India
2 Department of Haematology and Transfusion Medicine, Government Medical College & Hospital, Sector 32, Chandigarh, India

Correspondence Address:
V Agarwal
C1221, Sector 32B, Chandigarh - 160030
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Source of Support: None, Conflict of Interest: None

PMID: 15048003

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Three cases of rheumatoid arthritis (RA), presenting with refractory anaemia, thrombocytopenia and peripheral lymphocytosis respectively, were observed. In all the cases haematological manifestations were unrelated to disease activity or drug toxicity. These patients were detected to have pure red cell aplasia (PRCA) (normocytic normochromic anaemia, reticulocytopenia and absence of erythroid precursors in the bone marrow), immune thrombocytopenia (IT) (absence of splenomegaly and presence of increased megakaryocytes in the bone marrow) and multiple myeloma (MM) (lytic lesions on skull, paraproteinaemia and bone marrow plasmacytosis) respectively. PRCA and IT responded to glucocorticoids. Association with these three haematological alterations has rarely been reported. Our report highlights the need to regularly monitor blood counts in patients with RA.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow