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Year : 2004  |  Volume : 50  |  Issue : 3  |  Page : 197-199

Thrombotic thrombocytopenic purpura -induced posterior leukoencephalopathy in a patient without significant renal or hypertensive complications

Department of Neurology, Walter Reed Army Medical Center, 6900 Georgia Ave, NW, Bldg # 2, DC - 20307, USA

Correspondence Address:
John P Ney
Department of Neurology, Walter Reed Army Medical Center, 6900 Georgia Ave, NW, Bldg # 2, DC - 20307,
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Source of Support: None, Conflict of Interest: None

PMID: 15377805

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A 40-year-old male with recent-onset idiopathic thrombotic thrombocytopenic purpura (TTP) developed focal transient neurological findings lasting for several hours, remitting, then recurring in a different pattern. Brain magnetic resonance imaging (MRI) was consistent with a posterior leukoencephalopathy and electroencephalography demonstrated lateralized slowing during an episode. No acute ischemic changes were found on diffusion-weighted imaging. Close monitoring in an intensive care setting revealed no significant hypertensive episodes. The patientís condition resolved with plasmapheresis and immunoglobulin therapy. The relation of TTP to reversible posterior leukoencephalopathy syndromes is discussed. Clinical features of this case suggest a mechanism for TTP-induced leukoencephalopathy independent of hypertension and renal failure.


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Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow