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Year : 2005  |  Volume : 51  |  Issue : 1  |  Page : 43-44

Primary biliary cirrhosis complicated by transverse myelitis in a patient without Sjögren’s syndrome

1 First Department of Internal Medicine, Democritus University of Thrace, Greece
2 Department of Neurology, University General Hospital of Alexandroupolis, Greece

Correspondence Address:
Konstantinos Mimidis
First Department of Internal Medicine, Democritus University of Thrace
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Source of Support: None, Conflict of Interest: None

PMID: 15793339

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Transverse myelitis is an acute inflammatory process, affecting one or more segments of the spinal cord. Its association with primary biliary cirrhosis has been documented in only four cases – all along with Sjögren’s syndrome. Herein, we report for the first time, a patient who developed recurrent acute transverse myelitis in association with primary biliary cirrhosis without any clinical or histological indication of Sjögren’s syndrome. A 42-year-old woman with primary biliary cirrhosis developed acute onset quadriparesis and urinary retention. Diagnostic evaluation excluded the presence of Sjögren’s syndrome, other autoimmune syndromes, infections and multiple sclerosis. Magnetic resonance imaging of the spinal cord disclosed signal intensity abnormalities from C1 to T2 after gadolinium enhancement. As diagnosis of acute transverse myelitis was prominent, the patient was treated with intravenous methylprednisolone. The patient had a fair outcome despite an early recurrence of the symptoms after treatment withdrawal.


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Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow