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| CASE REPORT |
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| Year : 2005 | Volume
: 51
| Issue : 2 | Page : 119-121 |
Accumulation of Tc99m-DMSA-3 in the spleen in a case of multiple myeloma with associated amyloidosis
Sukanta Barai1, GP Bandopadhayaya1, M Rathi2, NG Singh3
1 Departments of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India
2 Departments of Medicine, All India Institute of Medical Sciences, New Delhi, India
3 Departments of Pathology, All India Institute of Medical Sciences, New Delhi, India
Correspondence Address:
Sukanta Barai
Departments of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 16006704 
We describe a case of a 58-year-old male with longstanding hypertension and Type 2 diabetes mellitus who developed sudden onset renal impairment. The first clue to the possible presence of amyloidosis in this case was provided by the radionuclide renal cortical scan performed with trivalent dimercapto succinic acid (Tc99m-DMSA-3), which revealed intense tracer uptake in the spleen suggesting amyloid deposit. Further workup to ascertain the cause of amyloidosis led to the diagnosis of multiple myeloma. We conclude that in cases of extra-renal or splenic accumulation of Tc99m-DMSA-3, a diagnosis of amyloidosis should be considered, in an appropriate clinical setting.
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