Journal of Postgraduate Medicine
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Year : 2005  |  Volume : 51  |  Issue : 4  |  Page : 326-327

Primary anaplastic large cell lymphoma of central nervous system-A case report

1 Department of Pathology, T. N. Medical College, B. Y. L. Nair Charitable Hospital, Mumbai, India
2 Tata Memorial Hospital, Mumbai, India

Correspondence Address:
A Rupani
Department of Pathology, T. N. Medical College, B. Y. L. Nair Charitable Hospital, Mumbai
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Source of Support: None, Conflict of Interest: None

PMID: 16388180

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Central nervous system (CNS) involvement is extremely rare in anaplastic large cell lymphoma (ALCL). Primary ALCL of CNS on radiology is often misdiagnosed as tuberculosis. We report a fatal case of primary ALCL of CNS in a 17 year old male. He came with history of headache and left partial seizures. MRI showed a well- circumscribed lesion in the right fronto-parietal lobe eroding the skull bone. Biopsy showed large pleomorphic cells. Immunohistochemical stains showed positivity for CD30, CD43, EMA and ALK-1. In spite of radiotherapy and steroids, patient expired. Hence a high level of suspicion is essential for early diagnosis and for instituting appropriate treatment.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow