Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & ISI's SCI  
Users online: 1535  
Home | Subscribe | Feedback | Login 
About Latest Articles Back-Issues Articlesmenu-bullet Search Instructions Online Submission Subscribe Etcetera Contact
 :: Next article
 :: Previous article 
 :: Table of Contents
 ::  Similar in PUBMED
 ::  Search Pubmed for
 ::  Search in Google Scholar for
 ::  Article in PDF (164 KB)
 ::  Citation Manager
 ::  Access Statistics
 ::  Reader Comments
 ::  Email Alert *
 ::  Add to My List *
* Registration required (free) 

  IN THIS Article
 ::  References
 ::  Article Figures

 Article Access Statistics
    PDF Downloaded186    
    Comments [Add]    
    Cited by others 3    

Recommend this journal


Year : 2005  |  Volume : 51  |  Issue : 4  |  Page : 335-336

Bilateral massive pleural effusion-A rare presentation of sarcoidosis

1 Departments of Medicine, Christian Medical College and Hospital, Vellore, India
2 Departments of Radiodiagnosis, Christian Medical College and Hospital, Vellore, India

Correspondence Address:
J Mathew
Departments of Medicine, Christian Medical College and Hospital, Vellore
Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 16388185

Rights and PermissionsRights and Permissions

How to cite this article:
Balasubramanian P, Mathew J, Cherian R, Abraham O C. Bilateral massive pleural effusion-A rare presentation of sarcoidosis. J Postgrad Med 2005;51:335-6

How to cite this URL:
Balasubramanian P, Mathew J, Cherian R, Abraham O C. Bilateral massive pleural effusion-A rare presentation of sarcoidosis. J Postgrad Med [serial online] 2005 [cited 2023 Sep 25];51:335-6. Available from:


A middle-aged lady presented to her physician with breathlessness on exertion, dry cough and weight loss. Histopathology of an enlarged right supraclavicular lymph node revealed necrotising granulomatous lymphadenitis. Hence with a diagnosis of tuberculosis adequate first line antituberculous therapy was given. As her symptoms worsened, Ciprofloxacin, Ethionamide and Kanamycin were added. These drugs were taken regularly for 13 months. Thereafter she discontinued all medications due to further worsening. Her chest radiograph showed bilateral interstitial shadows and small pleural effusions. Repeat right supraclavicular lymph node biopsy showed necrotising granulomas, and culture grew one colony of Mycobacterium tuberculosis. She was given Isoniazid, Rifampicin, Pyrazinamide, Sparfloxacin and Cycloserine. She still had no relief of symptoms despite good adherence to therapy for 11 months. She presented to us with worsening of breathlessness and dyspnoea at rest.

On examination, she was afebrile with tachypnea, tachycardia, central cyanosis, asterixis and bilateral pitting pedal oedema without elevation of JVP. She had three enlarged, firm, discrete, right supraclavicular lymph nodes. Chest examination revealed stony dullness to percussion over both lung bases with absent breath sounds over these areas. Rest of the physical examination was unremarkable.

Hemogram and blood biochemistry were normal. Mantoux test was negative. ABG showed pH- 7.41; pCO2 52.2 mmHg; pO2 44.6 mmHg; HCO3 32.6 mEq/l and saturation of 80.3%. Chest radiograph showed bilateral pleural effusions. HRCT scans [Figure - 1] revealed nodularity and marked thickening, predominantly along the central peribronchovascular interstitium. There was moderate bilateral pleural effusion. Subcarinal, paratracheal and anterior mediastinal nodes were enlarged, up to 12mm with some exhibiting areas of peripheral calcification [Figure - 2]. Pleural fluid analysis revealed an exudate with lymphocytic pleocytosis, bacterial, fungal and mycobacterial cultures were negative. Cytology was negative for malignant cells. Pleural biopsy revealed non-caseating granulomas and Mycobacterial culture of the pleural tissue was negative. Histology of right supraclavicular lymph node showed non-caseating granulomatous inflammation, and cultures were negative. Based on these clinico-radiologico-pathological features and non-response to anti-tuberculous therapy, she was diagnosed to have sarcoidosis.

She was initiated on corticosteroids and all antituberculous medications were discontinued. She had significant improvement of dyspnea and cyanosis disappeared. Repeat chest radiograph showed marked decrease in the effusion. Her follow up HRCT scans showed evidence of residual fibrosis with significant reduction in nodularity.

The presence of bilateral large effusions in sarcoidosis is unusual. The reported prevalence of pleural involvement in sarcoidosis varies from 0 to 5% [1] with unilateral, small effusions usually. Clinically significant bilateral effusions in sarcoidosis are rare. There are few other reports of sarcoidosis presenting with bilateral pleural effusions but the quantity of fluid was small and clinically insignificant.[2] The growth of one colony of Mycobacterium tuberculosis on culture from the lesion in our patient reiterate the possibility that mycobacteria or some of its components may be capable of inducing the immune response and the pathological changes of sarcoidosis.[3]

Hence, sarcoidosis is an important treatable differential diagnosis to be considered in a patient with bilateral pleural effusions especially in the setting of associated pulmonary involvement, non-caseating granulomas[4],[5] and non-response to antituberculous therapy.

 :: References Top

1.Yanardag H, Gunes Y. Occurrence of pleural effusion due to tuberculosis in patients with sarcoidosis. Indian J Chest Dis Allied Sci 2005;47:9-11.  Back to cited text no. 1  [PUBMED]  
2.Johnson MN, Martin ND, McNicol MW. Sarcoidosis presenting with pleurisy and bilateral pleural effusion. Postgrad Med J 1980;56:266-7.  Back to cited text no. 2    
3.Chi FW, Wing WY, Poon CW and Joseph Lee. A case of concomitant Tuberculosis and Sarcoidosis with Mycobacterial DNA present in the Sarcoid lesion. Chest 1998;11:626-9.   Back to cited text no. 3    
4.Nusair S, Kramer MR, Berkman N. Pleural effusion with splenic rupture as manifestations of recurrence of sarcoidosis following prolonged remission.Respiration 2003;70:114-7.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]
5.Watarai M, Yazawa M, Yamanda K,Yamamoto H, Yamazaki Y. Pulmonary sarcoidosis with associated bloody pleurisy. Intern Med 2002;41:1021-3.  Back to cited text no. 5  [PUBMED]  


[Figure - 1], [Figure - 2]

This article has been cited by
1 Recurrent massive pleural effusion with neurosarcoidosis: A rare presentation of sarcoidosis
Jayalaksmi, T.K., Lobo, I., Nair, G., Uppe, A., Swami, S.
Journal of Association of Physicians of India. 2010; 58(4): 243-244
2 Peritoneal and pleural sarcoidosis: An unusual association - Review and clinical report
Iyer, S., Afshar, K., Sharma, O.P.
Current Opinion in Pulmonary Medicine. 2008; 14(5): 481-487
3 Pulmonary sarcoidosis
Lynch JP, Ma YL, Koss MN, et al.


Print this article  Email this article
Previous article Next article
Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow