Journal of Postgraduate Medicine
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Year : 2005  |  Volume : 51  |  Issue : 5  |  Page : 21-26

Clinical manifestations and management of cryptococcal infection.


Department of Medicine Unit-I & Infectious Diseases, Christian Medical College, Vellore, Tamilnadu, India

Correspondence Address:
D Mathai
Department of Medicine Unit-I & Infectious Diseases, Christian Medical College, Vellore, Tamilnadu
India
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Source of Support: None, Conflict of Interest: None


PMID: 16519251

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Cryptococcus neoformans is an important fungal pathogen causing invasive infection, especially of the central nervous system in this era of the HIV/AIDS epidemic. The choice of treatment depends on site(s) of infection and the patient's immune status. Use of appropriate antifungal agents decreases mortality significantly, but requires continued therapy and long-term maintenance to prevent relapses. The use of liposomal amphotericin B (L Amp B) has overcome some of the difficulties usually found in this setting. The major advantage of these liposomal formulations are faster clearance of C. neoformans [cerebrospinal fluid (CSF) negative] and a reduction in amphotericin toxicity. The majority of clinical efficacy data related to L Amp B are derived from compassionate use studies and case series. Use of liposomal amphotericin has also shown to be a cost effective approach.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow