Journal of Postgraduate Medicine
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Year : 2006  |  Volume : 52  |  Issue : 3  |  Page : 197-200

Future implications: Compliance and failure with antiretroviral treatment

Infectious Diseases Clinic, Ahmedabad, Gujarat, India

Correspondence Address:
Atul K Patel
Infectious Diseases Clinic, Ahmedabad, Gujarat
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Source of Support: None, Conflict of Interest: None

PMID: 16855321

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HIV management is currently in an era of effective, potent antiretroviral therapy. Modern drug discovery and development have transformed HIV-1 disease into a treatable, chronic infectious disease. Complete suppression of viral replication is critical for long-term durability of antiretroviral therapy. Partial suppression, even at very low levels, is likely to lead to virologic failure and ultimately to the appearance of drug resistance. The relationship between adherence and resistance to HIV antiretroviral therapy is more complex than to state 'non-adherence increases the risk of drug resistance.' In many patients who fail to respond to initial therapy, the primary reason for failure is their inability to take the prescribed drug regimen or nonadherence.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow