Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & ISI's SCI  
Users online: 9029  
Home | Subscribe | Feedback | Login 
About Latest Articles Back-Issues Articlesmenu-bullet Search Instructions Online Submission Subscribe Etcetera Contact
 :: Next article
 :: Previous article 
 :: Table of Contents
 ::  Similar in PUBMED
 ::  Search Pubmed for
 ::  Search in Google Scholar for
 ::  Article in PDF (40 KB)
 ::  Citation Manager
 ::  Access Statistics
 ::  Reader Comments
 ::  Email Alert *
 ::  Add to My List *
* Registration required (free) 

  IN THIS Article
 ::  References

 Article Access Statistics
    PDF Downloaded341    
    Comments [Add]    
    Cited by others 4    

Recommend this journal


Year : 2008  |  Volume : 54  |  Issue : 2  |  Page : 83-84

Fournier's gangrene, still an enigma

University of Port Harcourt Teaching Hospital, Port Harcourt 500001, Nigeria

Correspondence Address:
N Eke
University of Port Harcourt Teaching Hospital, Port Harcourt 500001
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0022-3859.40770

Rights and Permissions

How to cite this article:
Eke N. Fournier's gangrene, still an enigma. J Postgrad Med 2008;54:83-4

How to cite this URL:
Eke N. Fournier's gangrene, still an enigma. J Postgrad Med [serial online] 2008 [cited 2023 Jun 10];54:83-4. Available from:

First documented in 1883 by Professor Jean-Alfred Fournier (1832-1914), Fournier's gangrene (FG) has continued to be of interest to physicians, especially now urologists. Women and children, not mentioned in the original report, are now known to suffer from it. However, reports on women remain scanty. It is suspected that involvement of women is underreported. [1] New reports, even if not offering much new, will continue to be relevant for continuing medical education because of continued late diagnosis by unsuspecting physicians. Each generation of doctors will first address issues in contemporary literature before recourse to past literature.

The diagnosis of FG is largely based on the clinical features, most importantly the anatomical area of the perineum and external genitalia. Thus both males and females are prone, as found by Unalp et al. , [2] in this issue. Radiological investigations as well as histopathology may assist in defining the extent of the disease and in monitoring response to treatment. In spite of efforts to determine prognostic factors, it has been difficult to significantly reduce the mortality and consequently morbidity also. The Fournier's gangrene severity index (FGSI) was proposed by Laor et al. in 1995 [3] to prognosticate on the outcome of the disease but does not seem to have impacted on the management universally. A part of the problem with universal application of the index lies in the low incidence of the disease, such that any one unit cannot recruit more than a limited number of patients in a period of practice. The two papers in this issue rank among the top 10 largest series on FG since 1990. Both are retrospective studies and one applied the index. In view of the low incidence of FG, it is necessary to design some prospective studies on the subject, conscious of the long period required for such a study to yield reliable and useful results. Collaborative multi-center studies are necessary. It has been observed that FGSI can be a useful basis to compare outcomes of management of FG. [4] Without recourse to the index, every patient should be treated on the basis of individual merit and considerations.

Although in this issue of the journal, the authors did not find that anorectal source of sepsis had a worse prognosis, there could be an explanation for the findings of many authors [1],[5],[6] that anorectal or colonic source of sepsis worsened prognosis. The anatomical area is awash with different types of organisms of varying virulence as well as synergism. The tissue planes permit organisms to spread. Testicular necrosis in FG is another indicator of severe disease as this points to retroperitoneal sepsis which causes thrombosis of the testicular blood vessels. [7] The retroperitoneal sepsis limits adequate drainage unless drainage is instituted through a laparotomy. Ultimately, sepsis and its complications account for the majority of deaths in FG. [7],[8]

The role of diabetes mellitus is reemphasized by the two authors in this issue with figures of 35.3% [2] and 51.3%. [9] In a previous review of 1726 cases published in the literature, [10] diabetes mellitus was a factor in 20% of the patients. However, it is yet to be settled by authors universally whether diabetes mellitus in FG is an etiological factor, a predisposing factor or merely a co-morbid factor. All may find application in specific instances.

The ultimate goal in the management of FG is to eliminate mortality. Mortality rates in FG vary from center to center and from region to region. In an unpublished study by this author, mortality rates are lowest in Africa and highest in NorthAmerica. This is in spite of advances in the management of afflicted persons. It is wise to treat every patient aggressively with available resources to prevent severe sepsis or stem the effects of sepsis. As stressed by the authors in this issue and others, aggressive treatment involves resuscitation with fluids and multiple parenteral antimicrobial agents and unrelenting excision of all necrotic tissues as they present. Many patients will be cured without the need for colostomy, grafts or hyperbaric oxygen treatment.

 :: References Top

1.Stephens BJ, Lathrop JC, Rice WT, Gruenberg JC. Fournier's gangrene: Historic (1764-1978) versus contemporary (1979-1988) differences in etiology and clinical importance. Am Surg 1993;59:149-54.  Back to cited text no. 1  [PUBMED]  
2.Unalp HR, Kamer E, Derici H, Atahan K, Balci U, Demirdoven C, et al . Fournier's gangrene: Evaluation of 68 patients and analysis of prognostic variables. J Postgrad Med June 2008;54:102-5.  Back to cited text no. 2    
3.Laor E, Palmer LS, Tolia BM, Reid RE, Winter HI. Outcome prediction in patients with Fournier's gangrene. J Urol 1995;154:89-92.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Chawla SN, Gallop C, Mydlo JH. Fournier's gangrene: An analysis of repeated surgical debridement. Eur Urol 2003;43:572-5.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]
5.Jeong HJ, Park SC, Seo IY, Rim JS. Prognostic factors in Fournier gangrene. Int J Urol 2005;12:1041-4.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]
6.Enriquez JM, Moreno S, Devesa M, Morales V, Platas A, Vicente E. Fournier's syndrome of urogenital and anorectal origin: Aretrospective, comparative study. Dis Colon Rectum 1987;30:33-7.  Back to cited text no. 6    
7.Moorthy K, Rao PP, Supe AN. Necrotising perineal infection: Afatal outcome of ischiorectal fossa abscesses. J R Coll Surg Edinb 2000;45:281-4.  Back to cited text no. 7  [PUBMED]  
8.Kuo CF, Wang WS, Lee CM, Liu CP, Tseng HK. Fournier's gangrene: Ten-year experience in a medical center in northern Taiwan. JMicrobiol Immunol Infect 2007;40:500-6.  Back to cited text no. 8    
9.Ghnnam WM. Fournier's gangrene in Mansoura Egypt: A review of 74 cases. J Postgrad Med June 2008;54:106-9.  Back to cited text no. 9    
10.Eke N. Fournier's gangrene: A review of 1726 cases. Br J Surg 2000;87:718-28.  Back to cited text no. 10  [PUBMED]  [FULLTEXT]

This article has been cited by
1 VAC (Vacuum Assisted Closure) treatment in Fournierśs gangrene: Personal experience and literature review
Assenza, M. and Cozza, V. and Sacco, E. and Clementi, I. and Tarantino, B. and Passafiume, F. and Valesini, L. and Bartolucci, P. and Modini, C.
Clinica Terapeutica. 2012; 162(SUPPL.1): e1-e5
2 Fournierśs gangrene
Inoue, K.
Japanese Journal of Clinical Urology. 2011; 65(1): 17-20
3 Fournierśs gangrene: Is it scrotal gangrene?
«akmak, A. and GenÁ, V. and Akyol, C. and Kayaoǧlu, H.A. and Hazinedaroǧlu, S.M.
Advances in Therapy. 2008; 25(10): 1065-1074
4 Fournierís gangrene: Is it scrotal gangrene?
Atil «akmak,Volkan GenÁ,Cihangir Akyol,H. Ayhan Kayaoglu,SelÁuk M. Hazinedaroglu
Advances in Therapy. 2008; 25(10): 1065
[Pubmed] | [DOI]


Print this article  Email this article
Previous article Next article
Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow