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| ADR REPORT |
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| Year : 2008 | Volume
: 54
| Issue : 4 | Page : 332-334 |
Nicolau syndrome following intramuscular benzathine penicillin
R De Sousa, A Dang, PV Rataboli
Department of Surgery, Goa Medical College, Bambolim, Goa - 403 202, India
Correspondence Address:
R De Sousa
Department of Surgery, Goa Medical College, Bambolim, Goa - 403 202
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0022-3859.43523
Nicolau syndrome (NS) is a rare complication of an intramuscular injection characterized by severe pain, skin discoloration, and varying levels of tissue necrosis. The case outcomes vary from atrophic ulcers and severe pain to sepsis and limb amputation. We describe a case of a seven-year-old boy with diagnosis of NS after intramuscular benzathine penicillin injection to the ventrolateral aspect of the left thigh. Characteristic violaceous discoloration of skin and immediate injection site pain identified it as a case of NS. The case was complicated by rapid progression of compartment syndrome of the lower limb, proceeding to acute renal failure and death. Associated compartment syndrome can be postulated as a poor prognostic factor for NS.
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