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| Year : 2012 | Volume
: 58
| Issue : 1 | Page : 84 |
Authors' Reply
RV Lohiya, SA Sangle
Department of Medicine, B. J. Medical College, Pune, Maharashtra, India
| Date of Web Publication | 25-Feb-2012 |
Correspondence Address:
S A Sangle
Department of Medicine, B. J. Medical College, Pune, Maharashtra
India
 Source of Support: None, Conflict of Interest: None  | Check |
How to cite this article:
Lohiya R V, Sangle S A. Authors' Reply. J Postgrad Med 2012;58:84 |
Sir,
We appreciate the interest shown by the author in our article. [1] The author has proposed an alternative mechanism for parotitis in a patient of organophosphorus compound (OPC) poisoning. As per the author blockage of the parotid duct due to thick mucoid salivary secretions and endotracheal intubation causes retention of the secretion leading to transient parotid gland enlargement. However, in our case ultrasonography of the parotid gland confirmed the patency of the parotid ducts and the patient did not require endotracheal intubation. Rise in serum amylase levels favored parotid cell lysis and cannot be explained on the basis of parotid duct obstruction. Simultaneous involvement of salivary and lacrimal glands indicates generalized inflammation of glandular tissues. Also, in an animal study by Gulalp et al., [2] parotitis was histopathologically documented in rats exposed to OPC and treated with atropine and pralidoxime. Thus mere mechanical obstruction of glandular ducts is insufficient to explain the occurrence of parotitis and dacroadenitis in OPC poisoning and whether the said mechanism holds true in our case is doubtful. The exact mechanism for this phenomenon still remains to be unfolded.
| :: References | |  |
| 1. | Lohiya R, Sangle S. Uncommon manifestation of organophosphorus poisoning. J Postgrad Med 2011;57:224-5. 
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| 2. | Gulalp B, Gokel Y, Gumurd ulu D, Seydaoglu G, Daglioglu K, Dikmen N, et al. The effect of parathion-methyl and antidotes on parotid and pancreatic glands: A pilot experimental study. Int J Toxicol 2007;26:383-8.
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