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Year : 2014  |  Volume : 60  |  Issue : 2  |  Page : 135-140

Is Cystatin-C superior to creatinine in the early diagnosis of contrast-induced nephropathy?: A potential new biomarker for an old complication

1 Department of Cardiology, Ufuk University, Ankara, Turkey
2 Department of Biochemistry, Ufuk University, Ankara, Turkey
3 Cardiology Clinic, Ankara Yuksek Ihtisas Education and Training Hospital, Ankara, Turkey
4 Department of Biostatistics, Ankara University, Ankara, Turkey

Correspondence Address:
Dr. A E Ebru
Department of Cardiology, Ufuk University, Ankara
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0022-3859.132317

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Background/Aims: The aim of this study was to assess whether changes in Cystatin C (CyC) after 48 h post contrast media exposure was a reliable indicator of acute kidney injury and the validity of a risk scoring tool for contrast-induced acute kidney injury (CI-AKI). Materials and Methods: We enrolled 121 patients for whom diagnostic coronary angiography were planned. The risk score for CI-AKI was calculated and serum creatinine (sCr) and CyC were measured before and 48 h post coronary angiography. CyC and sCr based AKI was calculated as a 25% increase from baseline within 48 h from contrast media exposure. Results: Mean serum CyC and creatinine concentrations were 0.88 ± 0.27 mg/dL and 0.79 ± 0.22 mg/dL, respectively before the procedure and 1.07 ± 0.47 mg/dL and 0.89 ± 0.36 mg/dL, respectively 48 h after contrast media exposure (P < 0.001). CyC based AKI occured in 45 patients (37.19 %) and sCr based AKI occured in 20 patients (16.52%) after the procedure. Mean risk score was found to be 4.00 ± 3.478 and 3.60 ± 4.122 for CyC based AKI and sCr based AKI, respectively and was significantly increased in CyC based AKI group (P < 0.001). Conclusions: CyC measured 48 h after contrast media exposure may be a more sensitive indicator of CI-AKI relative to creatinine and Mehran risk scoring is in good correlation with CyC increase.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow