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|Year : 2015 | Volume
| Issue : 1 | Page : 58-59
JR Wisler1, AN Springer2, K Hateley1, XM Mo3, DC Evans1, CH Cook1, AT Gerlach4, CV Murphy4, DS Eiferman1, SM Steinberg1, SD Bergese2, TJ Papadimos2, SP Stawicki5
1 Department of Surgery, Division of Trauma, Critical Care and Burn, College of Medicine, The Ohio State University, Columbus, Ohio, USA
2 Department of Anesthesiology, College of Medicine, The Ohio State University, Columbus, Ohio, USA
3 Center for Biostatistics, College of Medicine, The Ohio State University, Columbus, Ohio, USA
4 Department of Pharmacy, College of Medicine, The Ohio State University, Columbus, Ohio, USA
5 Department of Research and Innovation, St Luke's University Health Network, Bethlehem, Pennsylvania, USA
|Date of Web Publication||15-Dec-2014|
Dr. S P Stawicki
Department of Research and Innovation, St Luke's University Health Network, Bethlehem, Pennsylvania
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Wisler J R, Springer A N, Hateley K, Mo X M, Evans D C, Cook C H, Gerlach A T, Murphy C V, Eiferman D S, Steinberg S M, Bergese S D, Papadimos T J, Stawicki S P. Authors' reply. J Postgrad Med 2015;61:58-9
|How to cite this URL:|
Wisler J R, Springer A N, Hateley K, Mo X M, Evans D C, Cook C H, Gerlach A T, Murphy C V, Eiferman D S, Steinberg S M, Bergese S D, Papadimos T J, Stawicki S P. Authors' reply. J Postgrad Med [serial online] 2015 [cited 2021 Apr 11];61:58-9. Available from: https://www.jpgmonline.com/text.asp?2015/61/1/58/147062
We appreciate the insights from Bhad and Hazari.  The issue of polypharmacy in the elderly population is of increasing importance due to the rapidly aging population - A phenomenon of truly global proportions. , While the present study identifies several combinations of pre-injury cardiac and neuropsychiatric medications that may be associated with increased mortality following trauma, it is important to note that this paper is purely descriptive in nature and that no causative effect is claimed by the study team.  The authors would like to emphasize that they fully recognize limitations of the present study and have cautioned readers in the discussion about the generalizability of the findings. These data are reported purely as preliminary findings in a clinical area with little to no previous investigation along the current line of scientific inquiry.  We echo Bhad and Hazari's sentiment that the overarching issue at hand is not necessarily isolated to the use of neuro-psychiatric or cardiac medications but rather to the emerging phenomenon of polypharmacy and the secondary effects of multi-medication regimens that we are just now beginning to more fully appreciate. , We also agree that many of the patients taking neuro-psychiatric medications may not have been previously able to participate in activities that many others in the society take for granted, and have thus tremendously benefited from both the availability improving efficacy of these pharmaceutical agents. ,, Having said that, it is important to emphasize that the associations noted in the current study  are unlikely to be present purely by chance and that further investigation within this specific area is certainly warranted.
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