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N Dominguez-Pinilla; M Baro-Fernandez; LI Gonzalez-Granado

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LETTER

Year : 2015 \| Volume : 61 \| Issue : 2 \| Page : 145

Authors' reply

N Dominguez-Pinilla, M Baro-Fernandez, LI Gonzalez-Granado
Department of Pediatrics, Hematology and Oncology Unit, Hospital 12 Octubre, Madrid, Spain

Date of Web Publication

13-Mar-2015

Correspondence Address:
L I Gonzalez-Granado
Department of Pediatrics, Hematology and Oncology Unit, Hospital 12 Octubre, Madrid
Spain

Source of Support: None, Conflict of Interest: None

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How to cite this article:
Dominguez-Pinilla N, Baro-Fernandez M, Gonzalez-Granado L I. Authors' reply. J Postgrad Med 2015;61:145

How to cite this URL:
Dominguez-Pinilla N, Baro-Fernandez M, Gonzalez-Granado L I. Authors' reply. J Postgrad Med [serial online] 2015 [cited 2023 Jun 4];61:145. Available from: https://www.jpgmonline.com/text.asp?2015/61/2/145/153115

Sir,

We thank Chhabra P for their comments. ^[1] The HIV test in our patient returned negative (HIV tests during pregnancy were also negative). It has also been reported HLH in AIDS is secondary not to the virus itself, but to overwhelming infections (particularly Pneumocystis jiroveci and nontuberculous mycobacteria). Complex immune mechanisms in HIV-Leishmania have been reported elsewhere. ^[2] In our country comparison between different microbiological techniques has been reported. However, serology is neither sensitive nor specific in the general Spanish population ^[3] and in HIV patients. ^[4] Our data on file in a pediatric cohort of HLH-Leishmania patients shows that only 32% of patients had a positive urine test. Thus, in our country the most reliable test remains PCR in bone marrow samples, followed by PCR in peripheral blood.

:: References

1.	Chhabra P. Offender: Virus or parasite or both. J Postgrad Med 2015;61:145.
2.	Okwor I1, Uzonna JE. The immunology of Leishmania/HIV co-infection. Immunol Res. 2013 May; 56:163-71.
3.	Cruz I1, Chicharro C, Nieto J, Bailo B, Cañavate C, Figueras MC. Comparison of new diagnostic tools for management of pediatric Mediterranean visceral leishmaniasis. J Clin Microbiol. 2006;44:2343-7.
4.	García-García JA, Martín-Sánchez J, Gállego M, Rivero-Román A, Camacho A, Riera C et al. Use of noninvasive markers to detect Leishmania infection in asymptomatic human immunodeficiency virus-infected patients. J Clin Microbiol. 200;44:4455-8.