Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & ISI's SCI  
Users online: 3007  
Home | Subscribe | Feedback | Login 
About Latest Articles Back-Issues Article Submission Resources Sections Etcetera Contact
 
  NAVIGATE Here 
  Search
 
  
 RESOURCE Links
 ::  Similar in PUBMED
 ::  Search Pubmed for
 ::  Search in Google Scholar for
 ::  Article in PDF (243 KB)
 ::  Citation Manager
 ::  Access Statistics
 ::  Reader Comments
 ::  Email Alert *
 ::  Add to My List *
* Registration required (free) 

  IN THIS Article
 ::  References

 Article Access Statistics
    Viewed174    
    Printed2    
    Emailed0    
    PDF Downloaded2    
    Comments [Add]    

Recommend this journal


 


 
  Table of Contents     
LETTER
Year : 2020  |  Volume : 66  |  Issue : 3  |  Page : 178

Synovial chondromatosis of ankle in a child: A rare presentation


Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Date of Submission01-Apr-2020
Date of Decision16-Apr-2020
Date of Acceptance23-Apr-2020
Date of Web Publication17-Jun-2020

Correspondence Address:
M D Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad
Iraq
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpgm.JPGM_275_20

Rights and Permissions




How to cite this article:
Al-Mendalawi M D. Synovial chondromatosis of ankle in a child: A rare presentation. J Postgrad Med 2020;66:178

How to cite this URL:
Al-Mendalawi M D. Synovial chondromatosis of ankle in a child: A rare presentation. J Postgrad Med [serial online] 2020 [cited 2020 Oct 19];66:178. Available from: https://www.jpgmonline.com/text.asp?2020/66/3/178/289803




Sathe et al.[1] have described an interesting case report of chondromatosis in an Indian child. As chondromatosis tends to often occur in older age group, the author regrettably did not attempt to disclose the rare development of chondromatosis in a child. I presume that the following point might be explanatory. It is explicit that hydroxyglutaric aciduria (HGAU) is a rare autosomal recessive inherited neurometabolic condition. It is featured by the accumulation of abnormal quantity of D-2-hydroxyglutaric acid (D-2-HGA) in the urine, blood, and cerebrospinal fluid. The clinical picture widely differs from asymptomatic to severe encephalopathy.[2] A distinct variety of an unusual combination of metabolic abnormalities of HGAU and skeletal chondromatosis has been reported. Choo et al.[3] described 4 patients who presented with a severe form of metaphyseal chondromatosis associated with HGAU. As D-2-HGA was excreted in high quantity in the urine of all the four studied patients, Choo et al.[3] recommended that urine organic acid screening needs to be undertaken in chondromatosis patients. Although the case in question had no neurological abnormalities as described by Sathe,[1] HGAU could not be totally excluded. This is because the disease might follow an asymptomatic course.[2],[3] As the consanguineous marriage is still a noticeable phenomenon in India on one hand,[4] and the significant correlation of consanguinity with different kinds of inborn errors of the metabolism, including HGAU on the other,[5] I assume that HGAU ought to be critically considered in the case in question. If that was documented by the diagnostic panel of estimating D-2-HGA in various body fluids and mutational analysis, the case in question could be surely considered a novel case report of HGAU-associated chondromatosis in the pediatric literature.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
 :: References Top

1.
Sathe P, Agnihotri M, Vinchu C. Synovial chondromatosis of ankle in a child: A rare presentation. J Postgrad Med 2020;66:112-3.  Back to cited text no. 1
[PUBMED]  [Full text]  
2.
Kranendijk M, Struys EA, Salomons GS, Van der Knaap MS, Jakobs C. Progress in understanding 2-hydroxyglutaric acidurias. J Inherit Metab Dis 2012;35:571-87.  Back to cited text no. 2
    
3.
Choo HJ, Cho TJ, Song J, Tiller GE, Lee SH, Park G, et al. Metaphyseal chondromatosis combined with D-2-hydroxyglutaric aciduria in four patients. Skeletal Radiol 2012;41:1479-87.  Back to cited text no. 3
    
4.
Kumari N, Bittles AH, Saxena P. Has the long-predicted decline in consanguineous marriage in India occurred? J Biosoc Sci 2019:1-10. [in press].  Back to cited text no. 4
    
5.
Afzal RM, Lund AM, Skovby F. The impact of consanguinity on the frequency of inborn errors of metabolism. Mol Genet Metab Rep 2018;15:6-10.  Back to cited text no. 5
    




 

Top
Print this article  Email this article
 
Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow