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  Table of Contents     
Year : 2020  |  Volume : 66  |  Issue : 4  |  Page : 226

Idiopathic CD4+T lymphocytopenia: A case report

Dr Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia

Date of Submission22-Jun-2020
Date of Decision25-Jun-2020
Date of Acceptance31-Jul-2020
Date of Web Publication12-Oct-2020

Correspondence Address:
F A Damara
Dr Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpgm.JPGM_718_20

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How to cite this article:
Damara F A, Ramdhani A N. Idiopathic CD4+T lymphocytopenia: A case report. J Postgrad Med 2020;66:226

How to cite this URL:
Damara F A, Ramdhani A N. Idiopathic CD4+T lymphocytopenia: A case report. J Postgrad Med [serial online] 2020 [cited 2023 Oct 1];66:226. Available from:

Umamaheshwari et al have reported an interesting case of an individual suspected with Idiopathic CD4+ T Lymphopenia (ICL).[1] The case provides a comprehensive view of primary infections possibility leading to a significant decrease in CD4+ count. While Umamaheshwari et al. have stated that their patient was seronegative for human immunodeficiency virus (HIV), they have not provided detailed clinical history of the patient related to HIV risk-factors. In diagnosing HIV patients, HIV-risk behaviors [e.g., multiple sex partners, unprotected sexual intercourse, and intravenous (IV) drug use] need to be put on the priority before shifting to the confirmatory tests such as rapid diagnostic test (RDT), enzyme-linked immunosorbent assay (ELISA), and polymerase chain reaction (PCR). Furthermore, the type of HIV test that was used for the patient and whether the test was repeated is unclear. RDT has lower sensitivity and specificity compared to ELISA and PCR. RDT also depends on the natural history of HIV infection related to the time whether the antibody has been established or not. Although most of HIV testing have a relatively high rate of sensitivity and specificity, several factors may contribute to a false negative result; suboptimal testing strategies, poor management of supplies, and user errors including difficulty interpreting weak reactive lines.[2]

Lymphocytes are distributed on every lymph nodes including afferent lymph from gastrointestinal tissues. The loss of lymphocyte-rich lymph and disrupted lymph node architecture as the results from surgical procedures can result in in lymphopenia.[3] Therefore, patient history of toxic megacolon as a complication of ulcerative colitis needs to be elaborated, whether the patient was given immunosuppressive agent or only underwent surgery. Although it is more common in children, it is possible that the patient was having a transient lymphopenia in response to type I interferons (IFNs) from lymphocyte activation and binding to endothelium as the previous inflammation of ulcerative colitis had occurred.[4] Moreover, lymphocyte apoptosis and lymphoid depletion may result as consequences of high level of type I IFNs.[3],[4] Hence, assessing patient IFNs may add another perspective on disease progression of ICL and its treatment strategy.

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 :: References Top

Umamaheshwari S, Sumana MN, Shetty MS, Gopal S. Idiopathic CD4+T lymphocytopenia: A case report. J Postgrad Med 2020;66:102-4.  Back to cited text no. 1
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Johnson CC, Fonner V, Sands A, Ford N, Obermeyer CM, Tsui S, et al. To err is human, to correct is public health: A systematic review examining poor quality testing and misdiagnosis of HIV status. J Int AIDS Soc 2017;20(Suppl 6):21755.  Back to cited text no. 2
Harvey JW. Veterinary Hematology. In: Harvey JW, editor. Chapter 5 - Evaluation of Leukocytic Disorders. W.B. Saunders; 2012. pp. 122-76.  Back to cited text no. 3
Zonios D, Sheikh V, Sereti I. Idiopathic CD4 lymphocytopenia: A case of missing, wandering or ineffective T cells. Arthritis Res Ther 2012;14:222.  Back to cited text no. 4


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