Journal of Postgraduate Medicine
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Year : 1976  |  Volume : 22  |  Issue : 2  |  Page : 66-75  

Structure activity relationship of disubstituted piperazine compounds

NK Dadkar, Vaishali N Dadkar, CV Deliwala, UK Sheth 
 Department of Pharmacology and Pharmacology Research Unit CSIR. Seth G. S. Medical College, Parel, Bombay 400 012, India

Correspondence Address:
N K Dadkar
Hoechst Research Centre, Mulund, Bombay 400 080.
India

The various compounds belonging to the 1-4 disubstituted piperazine series exhibited the adrenolytic, hypotensive and CNS depressant activities. Appropriate substitution could also lead, to a dissociation of these pharmacological effects. It was observed that adrenolytic and CATS depressant but not the hypotensive pro­perty of these compounds was greatly susceptible to structural changes in their molecular configuration and a relationship was evident between adrenolytic and hypotensive activity as well as between CNS depressant and hypotensive activity with different structural variations.


How to cite this article:
Dadkar N K, Dadkar VN, Deliwala C V, Sheth U K. Structure activity relationship of disubstituted piperazine compounds.J Postgrad Med 1976;22:66-75


How to cite this URL:
Dadkar N K, Dadkar VN, Deliwala C V, Sheth U K. Structure activity relationship of disubstituted piperazine compounds. J Postgrad Med [serial online] 1976 [cited 2021 Jan 27 ];22:66-75
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=1976;volume=22;issue=2;spage=66;epage=75;aulast=Dadkar;type=0


 
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