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Structure activity relationship of disubstituted piperazine compounds
NK Dadkar, Vaishali N Dadkar, CV Deliwala, UK Sheth
Department of Pharmacology and Pharmacology Research Unit CSIR. Seth G. S. Medical College, Parel, Bombay 400 012, India
Correspondence Address:
N K Dadkar
Hoechst Research Centre, Mulund, Bombay 400 080.
India
The various compounds belonging to the 1-4 disubstituted piperazine series exhibited the adrenolytic, hypotensive and CNS depressant activities. Appropriate substitution could also lead, to a dissociation of these pharmacological effects. It was observed that adrenolytic and CATS depressant but not the hypotensive property of these compounds was greatly susceptible to structural changes in their molecular configuration and a relationship was evident between adrenolytic and hypotensive activity as well as between CNS depressant and hypotensive activity with different structural variations.
How to cite this article:
Dadkar N K, Dadkar VN, Deliwala C V, Sheth U K. Structure activity relationship of disubstituted piperazine compounds.J Postgrad Med 1976;22:66-75
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How to cite this URL:
Dadkar N K, Dadkar VN, Deliwala C V, Sheth U K. Structure activity relationship of disubstituted piperazine compounds. J Postgrad Med [serial online] 1976 [cited 2021 Jan 27 ];22:66-75
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=1976;volume=22;issue=2;spage=66;epage=75;aulast=Dadkar;type=0 |
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