A comparative study of central nervous system depressant effects of some of the disubstituted piperazine compounds-part I
NK Dadkar, Vaishali N Dadkar, UK Sheth
Department of Pharmacology and Pharmacology Research Unit C.S.I.R., Seth G. S. Medical College, Parel, Bombay 400 012, India
Comparison of central nervous system depressant activity of R-1230, R-1945 and R-1946 (disubstituted piperazine derivatives) employing various pharmacological tests revealed that R-1230 (Orthomethoxyphenyl derivative) and R-1946 (Parafluorophenyl derivative) were more potent than R-1945 (Orthof luorophenyl derivative) as CNS depressants and the CNS depression produced by these agents could be classified pharmacologically in same group as major tranquillizers like chlorpromazine. It also signified, that presence of methoxy or fluoro group within the drug molecule does not necessarily determine the activity but the position o f these groups in drug molecule is mainly responsible for determining degree of CNS depressant activity exerted by the compound.
N K Dadkar
Hoechst Research Centre, Mulund, Bombay 400080.
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Dadkar N K, Dadkar VN, Sheth U K. A comparative study of central nervous system depressant effects of some of the disubstituted piperazine compounds-part I.J Postgrad Med 1976;22:76-82
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Dadkar N K, Dadkar VN, Sheth U K. A comparative study of central nervous system depressant effects of some of the disubstituted piperazine compounds-part I. J Postgrad Med [serial online] 1976 [cited 2021 Jan 15 ];22:76-82
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