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Study of bioavailability of oral iron preparations
Kusum C Gupta1, Teresa Paul1, JM Mehta2, NK Desai1, Bharati Sanghvi3, UK Sheth1
1 Clinical Pharmacology Unit and the Clinical Drug Trial Unit, Council of Scientific & Industrial Research, Department of Pharmacology, Seth G. S. Medical College, & K.E.M. Hospital, Parel, Bombay 400 012., India
2 Department of Medicine, K.E.M. Hospital, Bombay 400012., India
3 Department of Statistics, University of Bombay, Bombay., India
Correspondence Address:
Kusum C Gupta
Clinical Pharmacology Unit and the Clinical Drug Trial Unit, Council of Scientific & Industrial Research, Department of Pharmacology, Seth G. S. Medical College, & K.E.M. Hospital, Parel, Bombay 400 012.
India
Two preparations o f oral iron, were evaluated in normal volunteers and in patients of iron deficiency anemia. The study in 10 normal volunteers measured the bioavailability of the two preparations. The study in 20 patients assessed the therapeutic equivalence and tolerance. In the volunteer study, serum iron levels at 4 and 8 hours were significantly higher with the iron vitamin-mineral combination than with the plain iron. The AUC was also significantly higher. In patients there was no difference in the effect of the two formulations. With both there was a rapid rise in Hb, PCV and reticulocyte count in the first week, after that the rate of increase was slow. Both preparations were equally well tolerated.
How to cite this article:
Gupta KC, Paul T, Mehta J M, Desai N K, Sanghvi B, Sheth U K. Study of bioavailability of oral iron preparations.J Postgrad Med 1976;22:94-99
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How to cite this URL:
Gupta KC, Paul T, Mehta J M, Desai N K, Sanghvi B, Sheth U K. Study of bioavailability of oral iron preparations. J Postgrad Med [serial online] 1976 [cited 2021 Jan 17 ];22:94-99
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=1976;volume=22;issue=2;spage=94;epage=99;aulast=Gupta;type=0 |
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