Journal of Postgraduate Medicine
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Year : 1977  |  Volume : 23  |  Issue : 4  |  Page : 156-160  

Clinical trial with intravenous clonidine in treatment of severe hypertension

UG Gadgil, JD Sunavalla, IJ Pinto, UK Sheth 
 Department of Cardiology, K.E.M, Hospital Bombay, and Clinical Pharmacology Unit of Department of Pharmacology, Seth G. S. Medical College and K.E.M. Hospital, Parel, Bombay-400 012., India

Correspondence Address:
U G Gadgil
Department of Cardiology, K.E.M, Hospital Bombay, and Clinical Pharmacology Unit of Department of Pharmacology, Seth G. S. Medical College and K.E.M. Hospital, Parel, Bombay-400 012.
India

Thirty six patients with severe hypertension were treated with intravenous clonidine. In 67% of cases maximum response was obtained within 11 hours of administration of the drug. Aver­age reduction in mean arterial pressure was 29%. Paradoxical rise in blood pressure was observed in some patients, immediately after clonidine administration. This could be prevented with prior administration of phentolamine intravenously. Clonidine (I.V.) sup­plied by two drug firms gave identical results.


How to cite this article:
Gadgil U G, Sunavalla J D, Pinto I J, Sheth U K. Clinical trial with intravenous clonidine in treatment of severe hypertension.J Postgrad Med 1977;23:156-160


How to cite this URL:
Gadgil U G, Sunavalla J D, Pinto I J, Sheth U K. Clinical trial with intravenous clonidine in treatment of severe hypertension. J Postgrad Med [serial online] 1977 [cited 2021 Jan 27 ];23:156-160
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=1977;volume=23;issue=4;spage=156;epage=160;aulast=Gadgil;type=0


 
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