Journal of Postgraduate Medicine
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ORIGINAL ARTICLE
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Year : 1991  |  Volume : 37  |  Issue : 1  |  Page : 5-8  

Antipyrine and doxycycline pharmacokinetics in patients with thyroid disorders.

VK Nayak, NK Desai, NA Kshirsagar, SD Bhandarkar, RS Satoskar 
 Department of Pharmacology, Seth G.S. Medical College, Parel, Bombay, Maharashtra.

Correspondence Address:
V K Nayak
Department of Pharmacology, Seth G.S. Medical College, Parel, Bombay, Maharashtra.

Pathological conditions are known to affect pharmacokinetics of many drugs. Antipyrine half-life is used as a marker of liver microsomal enzyme function. Antipyrine pharmacokinetics, therefore, was investigated in 23 thyrotoxic and 11 euthyroid goitre patients. Of these, 11 thyrotoxic and 9 euthyroid goitre patients also participated in doxycycline bioavailability studies. In thyrotoxic patients, antipyrine half-life and AUCo infinity and doxycycline Cpmax and AUCo infinity were found to be reduced as compared to those of healthy euthyroid normal subjects. Following treatment of thyrotoxicosis, the antipyrine half-life and AUCo infinity returned to normal. Doxycycline AUCo infinity returned to near normal range but Cpmax did not.


How to cite this article:
Nayak V K, Desai N K, Kshirsagar N A, Bhandarkar S D, Satoskar R S. Antipyrine and doxycycline pharmacokinetics in patients with thyroid disorders. J Postgrad Med 1991;37:5-8


How to cite this URL:
Nayak V K, Desai N K, Kshirsagar N A, Bhandarkar S D, Satoskar R S. Antipyrine and doxycycline pharmacokinetics in patients with thyroid disorders. J Postgrad Med [serial online] 1991 [cited 2022 Dec 10 ];37:5-8
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=1991;volume=37;issue=1;spage=5;epage=8;aulast=Nayak;type=0


 
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