Exudative v/s transudative ascites: differentiation based on fluid echogenicity on high resolution sonography.
HM Malde, RD Gandhi
Dept of Radiology, KEM Hospital, Parel, Bombay, Maharashtra.
H M Malde
Dept of Radiology, KEM Hospital, Parel, Bombay, Maharashtra.
Real time sonography was performed in 52 patients with ascites to evaluate the accuracy of sonography in differentiating an exudative from a transudative collection. The echogenicity of ascites was graded I, II and III using the echogenicity of normal abdominal viscera as comparative standard reference points. Grade I collections (31 patients) were either absolutely anechoic, or showed few internal echoes secondary to particulate matter. Grade II collections (7 patients) were hypoechoic as compared to the liver and spleen. Grade III collections (14 patients) had an echogenicity similar to or greater than that of the liver and spleen. The results of diagnostic aspiration in all patients were then compared to the sonographic grade of the ascitic fluid. All transudates (28 patients) had a Grade I echogenicity. Only 3 patients with an exudative ascites had a Grade I echogenicity. The remaining 21 patients with an exudative collection had an echogenicity equal to or greater than Grade II. Using these results, an ascitic fluid echogenicity of Grade I had a 92.32% sensitivity, 100% specificity, a positive predictive value of 1 and a negative predictive value of 0.875 in diagnosing transudates. An ascitic fluid echogenicity of Grade II or more had a sensitivity of 87.5%, specificity of 100%, a positive predictive value of 1 and a negative predictive value of 0.903 in diagnosing transudates.
|How to cite this article:|
Malde H M, Gandhi R D. Exudative v/s transudative ascites: differentiation based on fluid echogenicity on high resolution sonography. J Postgrad Med 1993;39:132-3
|How to cite this URL:|
Malde H M, Gandhi R D. Exudative v/s transudative ascites: differentiation based on fluid echogenicity on high resolution sonography. J Postgrad Med [serial online] 1993 [cited 2023 Jun 10 ];39:132-3
Available from: https://www.jpgmonline.com/text.asp?1993/39/3/132/616
Cirrhosis and abdominal tuberculosis are amongst the commonest causes of ascites in our country. As ultrasonography (USG) is the primary radiological investigation in these patients, the ability to distinguish transudative from exudative ascites using this modality, would obviously simplify the further diagnostic work-up and management off these patients. An attempt was made using current, high resolution sonographic equipment, to distinguish exudative from transudative ascites based on the echogenicity of the fluid.
Fifty-two patients with ascites (42 males and 10 females; mean age - 37 yrs) were subjected to real-time sonography using one of the new generation high resolution ultrasound equipment (Sonoline AC, Siemens Inc. Germany). A routine (3.5 MHz) sector transducer was followed by a high frequency (7.5 MHz) transducer, to compare the echogenicity of the ascites with the echogenicity of the normal abdominal viscera, and based on this, these fluid collections were graded as:
Grade I : anechoic (may show few internal echoes due to floating particulate matter).
Grade II : hypoechoic as compared to the liver and spleen.
Grade III : echogenicity similar to or slightly greater than that of the liver and spleen.
The sonographic appearance of the fluid collection in each patient was then compared with the findings of diagnostic aspiration.
Twenty-eight of the 52 patients reveafed a transudate on biochemical examination of the fluid obtained at diagnostic aspiration. The echogenicity of the ascitic fluid on sonography in each of these 28 patients was of Grade I.
The other 24 patients had an exudative collection as determined by the results of diagnostic aspiration. Twenty-one of these 24 patients had shown on sonography, echogenicity of Grade II or Grade III, while in 3 of 24 ascitic fluid showed a Grade I echogenicity.
A statistical analysis of our results show that an ascitic fluid echogenicity of Grade I has a sensitivity of 90.32%, specificity of 100%, positive predictive value of I and a negative predictive value of 0.875 in diagnosing transudates. An ascitic fluid echogenicity of Grade II or Grade III has a sensitivity of 87.5%, specificity of 100%, positive predictive value of 1 and a negative predictive value of 0.903 in diagnosing exudates.
The evaluation of a patient with ascites requires that the cause of the ascites be established. A useful framework for the work-up starts with an analysis of whether the fluid is an exudate or a transudate. This distinction is necessary even when the cause of the ascites seems obvious. Diagnostic paracentesis thus, remains the investigation of choice for the routine evaluation of a patient with ascites.
Over the past 2 decades, sonography has revolutionized the work- up of these patients. Apart from guiding diagnostic aspirations, especially of small fluid collections, USG also frequently demonstrates the causative factor responsible for their occurrence (e.g. cirrhosis, hepatoma etc.). However, the utility of sonography in differentiating transudates from exudates has remained variable,,,. Several ancillary findings have been suggested including the presence of fixed or mobile fibrinous strands and septations, fluid loculation, mesenteric thickening with adherent small bowel loops, hepatomegaly with or without distinct hepatic metastases, splenomegaly, lymphadenopathy, ileal wall thickening and diffuse thickening of the greater omenturn for differentiating the exudates ascites from a transudative one,,,. However, they are unfortunately absent in a significant proportion of these patients. In fact, a recent study on a large number of patients with tuberculous peritonitis of the wet- ascitic type reports that none of these findings were present in 52% of patients with an exudative ascites. This clearly outlines the need for more sensitive sonographic criteria to aid the differentiation of exudative from transudative ascites. In addition, we feel that the poor resolution of the older US equipment along with the complex and subjective sonographic criteria used by previous investigators compounded these difficulties.
We conclude from our present study, using the newer generation of high resolution US equipment, coupled with simple and objective grading criteria, that the echogenicity of the ascitic fluid can be a very useful predictive factor in differentiating exudates from transudates.
|1||Glickman RM, Isselbacker KJ Abdominal swelling and ascites. InWilson JD, Braunwald E, et al Eds. Harrison's Principles of Internal Medicine, 12th ed. New York: Mcgraw-Hill Inc; 1991, pp 270-271.|
|2||Edell SL, Gefter WB. Ultrasonic differentiation of types of ascitic fluid. AJR 1979; 133:111-114.|
|3||Lee DH, Lim JH, Ko YT, Yoon Y. Sonographic findings in tuberculous peritonitis of wet-ascitic type. Clin Radiol 1991; 44:306-310.|
|4||Vincent LM. The Peritoneal cavity and abdominal wall. In: Mittelstaedt CA, editor. Abdominal Ultrasound. New York: Churchill Livingstone; 1987, pp 501-564.|
|5||Weill FS. Ultrasound Diagnosis of Digestive Diseases, 3rd ed. Berlin: Springer-Veriag; 1990, pp 255-294. |