Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & EMBASE  
     Home | Subscribe | Feedback  

PAPERS
[View FULLTEXT] [Download PDF
 
Year : 1994  |  Volume : 40  |  Issue : 4  |  Page : 204-7  

An analysis of children with typhoid fever admitted in 1991.

CT Deshmukh, UB Nadkarni, SC Karande 
 Dept. of Pediatrics, KEM Hospital, Parel, Bombay, Maharashtra.

Correspondence Address:
C T Deshmukh
Dept. of Pediatrics, KEM Hospital, Parel, Bombay, Maharashtra.

In 28 children, with bacteriologically and/or serologically diagnosed typhoid fever treated at KEM Hospital, Bombay in 1991, initially one of the three recommended drugs (viz. chloramphenicol, amoxycillin or co-trimoxazole) was given for 7 days for defervescence to occur. In those who failed to respond, a second trial of therapy with one of the other two drugs was initiated, after omitting the first drug. A second failure of therapy was taken as an indication to use ciprofloxacin singly. Eventually, 18 (64.3%) cases responded to chloramphenicol or amoxycillin or co-trimoxazole. Ciprofloxacin was used in 19(35.7%) cases. the failure rate of treatment with chloramphenicol was 50%, with amoxycillin 71.4%, with co-trimoxazole 75% and 0% with ciprofloxacin. An analysis of the 28 cases revealed that apart from fever (in 100%), splenomegaly (in 82.1%) was the most important clinical pointer to diagnosis, along with absolute eosinopenia (in 71.4%). There were no major complications, except 2 cases with typhoid hepatitis who responded to choramphenicol and co-trimoxazole, respectively. Blood culture grew Salmonella typhi in 7 cases, of which 5 (72%) were multidrug resistant S. typhi. There were no characteristic clinical features to identify multi-drug resistant typhoid fever.


How to cite this article:
Deshmukh C T, Nadkarni U B, Karande S C. An analysis of children with typhoid fever admitted in 1991. J Postgrad Med 1994;40:204-7


How to cite this URL:
Deshmukh C T, Nadkarni U B, Karande S C. An analysis of children with typhoid fever admitted in 1991. J Postgrad Med [serial online] 1994 [cited 2020 Nov 30 ];40:204-7
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=1994;volume=40;issue=4;spage=204;epage=7;aulast=Deshmukh;type=0


 
Monday, November 30, 2020
 Site Map | Home | Contact Us | Feedback | Copyright  and disclaimer