Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & EMBASE  
     Home | Subscribe | Feedback  

ORIGINAL ARTICLE
[View FULLTEXT] [Download PDF
 
Year : 2000  |  Volume : 46  |  Issue : 4  |  Page : 258-61  

Antiphospholipid antibody positive young stroke: an analysis of 12 cases.

A Panagariya, A Garg, RK Sureka 
 Department of Neurology, SMS Medical College & Hospital, Jaipur - 302 004, India. , India

Correspondence Address:
A Panagariya
Department of Neurology, SMS Medical College & Hospital, Jaipur - 302 004, India.
India

AIMS AND OBJECTIVES: To study clinico-investigative profile of 12 young (<45 years) patients with stroke who tested positive for anti phospholipid antibodies (APLA). SUBJECTS AND METHODS: The diagnostic, clinical, laboratory and radiologic features in 12 APLA positive young patients who presented with stroke were studied. The APLA analysis included estimation of anticardiolipin (aCL) antibodies and lupus anticoagulant (LA). Other relevant tests included anti-nuclear antibody, human immunodeficiency virus, Venereal Diseases Research Laboratory, platelet count, echocardiography and carotid Doppler. APLA positive strokes were those cases where either the immunoglobulin G (IgG) and immunoglobulin M (IgM) were raised or LA was positive, and other known causes were excluded. RESULTS: Levels of IgG (aCL) was raised in 11 cases (mild 7, moderate 1, high 3), IgM was elevated in all the 12 cases (moderate 2, high 10). Of the two LA positive cases both were IgM positive but in one IgG was negative. Five patients showed small multiple bilateral cerebral infarcts on computerised tomography (CT) scan. 5 patients had history of recurrent strokes. Hemiparesis was more frequent than hemiplegia. None presented with dense hemiplegia. All patients recovered to normal functional capacity and did not have recurrence on drugs. CONCLUSION: A preliminary study on APLA positive young strokes showed certain clinical and radiological features, mild to moderate stroke, pre-treatment recurrences, multiple smaller infarcts on CT, which could be clustered in a subgroup of stroke in young. Incidentally these patients showed a good prognosis in terms of long term outcome.


How to cite this article:
Panagariya A, Garg A, Sureka R K. Antiphospholipid antibody positive young stroke: an analysis of 12 cases. J Postgrad Med 2000;46:258-61


How to cite this URL:
Panagariya A, Garg A, Sureka R K. Antiphospholipid antibody positive young stroke: an analysis of 12 cases. J Postgrad Med [serial online] 2000 [cited 2022 May 24 ];46:258-61
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=2000;volume=46;issue=4;spage=258;epage=61;aulast=Panagariya;type=0


 
Tuesday, May 24, 2022
 Site Map | Home | Contact Us | Feedback | Copyright  and disclaimer