Journal of Postgraduate Medicine
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Year : 2001  |  Volume : 47  |  Issue : 3  |  Page : 165-70  

Hypertrophic cardiomyopathy: an autopsy analysis of 14 cases.

RS Phadke, P Vaideeswar, B Mittal, J Deshpande 
 Department of Pathology, Seth G. S. Medical College and K. E. M. Hospital, Mumbai, India. , India

Correspondence Address:
R S Phadke
Department of Pathology, Seth G. S. Medical College and K. E. M. Hospital, Mumbai, India.
India

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is one of the less common forms of primary cardiomyopathies. There is little data available on HCM in Indian literature. AIMS: To assess the incidence and analyse the clinicopathological features of HCM. SETTINGS: Analysis of data of 15 years from a tertiary care centre. METHODS AND MATERIAL: The clinical and pathological data in fourteen cases of HCM with respect to their gross and microscopic features and clinical presentation were reviewed. RESULTS: Incidence of HCM amongst the autopsied primary cardiomyopathies (N = 101) was 13.9% (n=14). Males were affected more. Common presenting symptoms were exertional dyspnoea, angina and palpitations. Concentric and asymmetric hypertrophy was equally seen. Obliterative small vessel disease was noted in 50% of the cases. Although significant myofibre disarray (>5%) was seen in all fourteen cases, it could be demonstrated in only 40- 50% of an average of twenty sections studied. Type IA myofibre disarray was the commonest. Six of the fourteen patients died suddenly. Cardiac failure was the commonest cause of death. CONCLUSIONS: Myofibre disarray is a highly sensitive and specific marker for HCM only when considered in a quantitative rather than a qualitative fashion. In this context, the rationale for performing endomyocardial biopsy is to rule out mimics of HCM.


How to cite this article:
Phadke R S, Vaideeswar P, Mittal B, Deshpande J. Hypertrophic cardiomyopathy: an autopsy analysis of 14 cases. J Postgrad Med 2001;47:165-70


How to cite this URL:
Phadke R S, Vaideeswar P, Mittal B, Deshpande J. Hypertrophic cardiomyopathy: an autopsy analysis of 14 cases. J Postgrad Med [serial online] 2001 [cited 2021 Apr 14 ];47:165-70
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=2001;volume=47;issue=3;spage=165;epage=70;aulast=Phadke;type=0


 
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