Clinical manifestations and management of cryptococcal infection.
S Subramanian, D Mathai
Department of Medicine Unit-I & Infectious Diseases, Christian Medical College, Vellore, Tamilnadu, India
Cryptococcus neoformans is an important fungal pathogen causing invasive infection, especially of the central nervous system in this era of the HIV/AIDS epidemic. The choice of treatment depends on site(s) of infection and the patient«SQ»s immune status. Use of appropriate antifungal agents decreases mortality significantly, but requires continued therapy and long-term maintenance to prevent relapses. The use of liposomal amphotericin B (L Amp B) has overcome some of the difficulties usually found in this setting. The major advantage of these liposomal formulations are faster clearance of C. neoformans [cerebrospinal fluid (CSF) negative] and a reduction in amphotericin toxicity. The majority of clinical efficacy data related to L Amp B are derived from compassionate use studies and case series. Use of liposomal amphotericin has also shown to be a cost effective approach.
Department of Medicine Unit-I & Infectious Diseases, Christian Medical College, Vellore, Tamilnadu
|How to cite this article:|
Subramanian S, Mathai D. Clinical manifestations and management of cryptococcal infection. J Postgrad Med 2005;51:21-26
|How to cite this URL:|
Subramanian S, Mathai D. Clinical manifestations and management of cryptococcal infection. J Postgrad Med [serial online] 2005 [cited 2020 Dec 1 ];51:21-26
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=2005;volume=51;issue=5;spage=21;epage=26;aulast=Subramanian;type=0