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Severe nitrofurantoin lung disease resolving without the use of steroids
S Bhullar1, SM Lele2, S Kraman1
1 Division of Pulmonary, Critical Care and Sleep, Department of Internal Medicine, University of Kentucky, Lexington, United Kingdom
2 Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky, United Kingdom
Correspondence Address:
S Kraman
Division of Pulmonary, Critical Care and Sleep, Department of Internal Medicine, University of Kentucky, Lexington
United Kingdom
We report a case of an elderly woman who developed a severe, chronic pulmonary reaction to nitrofurantoin therapy that she had taken continuously for three years to prevent urinary tract infections. The patient was taking no other drug known to cause lung disease but the diagnosis was delayed by failure to recognize the association between nitrofurantoin and adverse drug reactions affecting the lung. When originally seen, the patient was unable to care for herself due to dyspnea. Bronchoscopy with biopsy ruled out other causes of her pulmonary disease. Immediate withdrawal of nitrofurantoin led to substantial, sustained improvement and disappearance of symptoms over several months without administration of corticosteroids. Nitrofurantoin toxicity should always be considered in any person taking that drug who develops bilateral infiltrates.
How to cite this article:
Bhullar S, Lele S M, Kraman S. Severe nitrofurantoin lung disease resolving without the use of steroids.J Postgrad Med 2007;53:111-113
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How to cite this URL:
Bhullar S, Lele S M, Kraman S. Severe nitrofurantoin lung disease resolving without the use of steroids. J Postgrad Med [serial online] 2007 [cited 2023 Sep 29 ];53:111-113
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=2007;volume=53;issue=2;spage=111;epage=113;aulast=Bhullar;type=0 |
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