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Adult mesenchymal stem cells: Differentiation potential and therapeutic applications
L Jackson, DR Jones, P Scotting, V Sottile
Wolfson Centre for Stem Cells, Tissue Engineering and Modelling ('STEM'), University of Nottingham, Nottingham NG7 2UH, United Kingdom
Correspondence Address:
V Sottile
Wolfson Centre for Stem Cells, Tissue Engineering and Modelling («SQ»STEM«SQ»), University of Nottingham, Nottingham NG7 2UH
United Kingdom
Adult mesenchymal stem cells (MSCs) are a population of multipotent cells found primarily in the bone marrow. They have long been known to be capable of osteogenic, adipogenic and chondrogenic differentiation and are currently the subject of a number of trials to assess their potential use in the clinic. Recently, the plasticity of these cells has come under close scrutiny as it has been suggested that they may have a differentiation potential beyond the mesenchymal lineage. Myogenic and in particular cardiomyogenic potential has been shown in vitro . MSCs have also been shown to have the ability to form neural cells both in vitro and in vivo , although the molecular mechanisms underlying these apparent transdifferentiation events are yet to be elucidated. We describe here the cellular characteristics and differentiation potential of MSCs, which represent a promising stem cell population for future applications in regenerative medicine.
How to cite this article:
Jackson L, Jones D R, Scotting P, Sottile V. Adult mesenchymal stem cells: Differentiation potential and therapeutic applications.J Postgrad Med 2007;53:121-127
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How to cite this URL:
Jackson L, Jones D R, Scotting P, Sottile V. Adult mesenchymal stem cells: Differentiation potential and therapeutic applications. J Postgrad Med [serial online] 2007 [cited 2023 Sep 30 ];53:121-127
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=2007;volume=53;issue=2;spage=121;epage=127;aulast=Jackson;type=0 |
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