Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & EMBASE  
     Home | Subscribe | Feedback  

ORIGINAL ARTICLE
[View FULLTEXT] [Download PDF
 
Year : 2008  |  Volume : 54  |  Issue : 2  |  Page : 110-114  

Characterization of adult onset growth hormone deficiency syndrome in patients with hypothalamopituitary diseases: Asian Indian data

TR Bandgar, M Prashanth, SR Joshi, PS Menon, NS Shah 
 Department of Endocrinology, Seth G. S. Medical College and K. E. M. Hospital, Parel, Mumbai, India

Correspondence Address:
T R Bandgar
Department of Endocrinology, Seth G. S. Medical College and K. E. M. Hospital, Parel, Mumbai
India

Background: Hardly any data is available on Adult onset growth hormone deficiency (AOGHD) in Patients with hypothalamopituitary diseases in India. Aims: To characterize Asian Indian AOGHD syndrome in hypothalamopituitary diseases. Settings and Design: Cross-sectional analysis of data from a tertiary care hospital. Materials and Methods: Thirty patients with AOGHD were compared with 30 age-, sex-, body mass index-matched controls with respect to endocrine evaluation, biochemistry, body composition (BC), bone mineral density (BMD), cardiovascular risk profile and quality of life (QoL). Statistical Analysis Used: Comparisons were performed using two-tailed Student«SQ»s test (SPSS Software version 10.0). Results: Most of the patients had abnormal BC with central obesity [Truncal FM (%): males {33.9±4.4 (patient) vs. 29.31±6.2 (control); P -0.027}; females {39.87±5.93 (patient) vs. 35.76±3.16 (control); P - 0.025}] and poor QoL. Patients aged over 45 years did not show low bone mass or lipid abnormalities as compared to controls. Low BMD and abnormal lipid profile {Triglycerides [mg/dl]:170.55±72.5 (patient) vs101.24±31.0 (control); P -0.038}; {very low density lipoprotein cholesterol [mg/dl]: 33.54±14.9 (patient) vs. 20.25±6.18 (control); P - 0.05} was seen in female patients less than 45 years of age. Conclusions: Male and female (more than 45 years) AOGHD patients have increased cardiovascular risk factors and poor QoL while BMD is unaffected. Females less than 45 years of age have the major characteristics of AOGHD and would be the group to benefit maximally with recombinant human Growth Hormone treatment, which is similar to that in the western literature.


How to cite this article:
Bandgar T R, Prashanth M, Joshi S R, Menon P S, Shah N S. Characterization of adult onset growth hormone deficiency syndrome in patients with hypothalamopituitary diseases: Asian Indian data.J Postgrad Med 2008;54:110-114


How to cite this URL:
Bandgar T R, Prashanth M, Joshi S R, Menon P S, Shah N S. Characterization of adult onset growth hormone deficiency syndrome in patients with hypothalamopituitary diseases: Asian Indian data. J Postgrad Med [serial online] 2008 [cited 2021 Mar 4 ];54:110-114
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=2008;volume=54;issue=2;spage=110;epage=114;aulast=Bandgar;type=0


 
Thursday, March 4, 2021
 Site Map | Home | Contact Us | Feedback | Copyright  and disclaimer