Journal of Postgraduate Medicine
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CASE REPORT
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Year : 2008  |  Volume : 54  |  Issue : 4  |  Page : 316-317  

Life-threatening overdose with lamotrigine, citalopram, and chlorpheniramine

N Venkatraman1, D O'Neil2, AP Hall3 
1 Acute Care Common Stem, University Hospitals of Leicester NHS Trust, Intensive Care Unit, Leicester Royal Infirmary, Leicester, United Kingdom
2 SpR Anesthetics, University Hospitals of Leicester NHS Trust, Intensive Care Unit, Leicester Royal Infirmary, Leicester, United Kingdom
3 Anesthesia and Intensive Care Medicine, University Hospitals of Leicester NHS Trust, Intensive Care Unit, Leicester Royal Infirmary, Leicester, United Kingdom

Correspondence Address:
N Venkatraman
Acute Care Common Stem, University Hospitals of Leicester NHS Trust, Intensive Care Unit, Leicester Royal Infirmary, Leicester
United Kingdom

Lamotrigine is a commonly used agent for seizure control in epilepsy. There are limited data on the adverse effects of lamotrigine in overdose. We report a number of serious side-effects associated with a large overdose of lamotrigine. A 23-year-old female presented to the emergency department after taking an intentional overdose of 9.2 g of lamotrigine, 56 mg of chlorpheniramine, and 220 mg of citalopram. On admission, she had a reduced level of consciousness and electrocardiographic abnormalities; a widened QRS and a prolonged corrected QT (QTc) interval. Prompt treatment with early intubation, along with the use of magnesium for cardioprotection and administration of sodium bicarbonate may have aided in a quick recovery with a short intensive care stay and good outcome.


How to cite this article:
Venkatraman N, O'Neil D, Hall A P. Life-threatening overdose with lamotrigine, citalopram, and chlorpheniramine.J Postgrad Med 2008;54:316-317


How to cite this URL:
Venkatraman N, O'Neil D, Hall A P. Life-threatening overdose with lamotrigine, citalopram, and chlorpheniramine. J Postgrad Med [serial online] 2008 [cited 2021 Sep 23 ];54:316-317
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=2008;volume=54;issue=4;spage=316;epage=317;aulast=Venkatraman;type=0


 
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