Journal of Postgraduate Medicine
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LETTER
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Year : 2009  |  Volume : 55  |  Issue : 1  |  Page : 73-74  

Primary gastric mucormycosis: Role of preexisting ulcerative and erosive lesions

SPE Benjamin 
 School of Medicine, AIMST University, 31 / 2, Bukit Air Nasi, Jalan Bedong Semeling, 08100 Bedong, Kedah Darul Aman, West Malaysia

Correspondence Address:
SPE Benjamin
School of Medicine, AIMST University, 31 / 2, Bukit Air Nasi, Jalan Bedong Semeling, 08100 Bedong, Kedah Darul Aman, West Malaysia




How to cite this article:
Benjamin S. Primary gastric mucormycosis: Role of preexisting ulcerative and erosive lesions.J Postgrad Med 2009;55:73-74


How to cite this URL:
Benjamin S. Primary gastric mucormycosis: Role of preexisting ulcerative and erosive lesions. J Postgrad Med [serial online] 2009 [cited 2022 Jun 29 ];55:73-74
Available from: https://www.jpgmonline.com/text.asp?2009/55/1/73/48447


Full Text

Sir,

The article entitled "Primary gastrointestinal mucormycosis in an immunocompetent person" by Shiva Prasad et al., [1] in the July 2008 edition of the Journal of Postgraduate Medicine was informative. Though the authors consider that there are no predisposing factors, the presence of a gastric ulcer may be considered a predisposing factor. An unperforated gastric ulcer of this size is likely to be chronic. Acute ulcers are often small and multiple. Predisposing factors for gastric ulcers like smoking, alcohol ingestion, etc need to be mentioned. [2],[3] Gastric mucormycosis has been reported in smokers and alcoholics. [2],[3],[4] Even in the immunocompromised it is more often seen in patients who have risk factors for ulcerative or erosive gastritis. It is more often reported with transplant recipients who are on steroids than in other immunosuppressed states. [5],[6] Often the underlying peptic ulcer disease may be asymptomatic. Some authors have suspected it on the basis of circumstantial evidence or the presence of subserosal fibrosis on gastrectomy specimen. [5],[7] A study of 20 cases of gastrointestinal mucormycosis found that 10 of them had peptic ulcer disease. [8] Prednisolone-induced gastrointestinal mucormycosis has been demonstrated in animal studies. [9] In the absence of systemic immunosuppression, a breach in the gastric mucosa might be an important predisposing factor for the condition.

References

1Shiva Prasad BN, Shenoy A, Nataraj KS. Primary gastrointestinal mucormycosis in an immunocompetent person. J Postgrad Med 2008;54:211-3.
2Jung JH, Choi HJ, Yoo J, Kang SJ, Lee KY. Emphysematous gastritis associated with invasive gastric mucormycosis: A case report. J Korean Med Sci 2007;22:923-7.
3Park YS, Lee JD, Kim TH, Joo YH, Lee JH, Lee TS, et al . Gastric mucormycosis. Gastrointest Endosc 2002;56:904-5.
4Ho YH, Wu BG, Chen YZ, Wang LS. Gastric mucormycosis in an alcoholic with review of the literature. Tzu Chi Medical Journal. 2007;19:169-72.
5Corley DA, Lindeman N, Ostroff JW. Survival with early diagnosis of invasive gastric mucormycosis in a heart transplant patient. Gastrointest Endosc 1997;46:452-4.
6Winkler S, Susani S, Willinger B, Apsner R, Rosenkranz AR, Pφtzi R, et al. Gastric mucormycosis due to Rhizopus oryzae in a renal transplant recipient. J Clin Microbiol 1996;34:2585-7.
7Schulman A, Bornman P, Kaplan C, Morton P, Rose A. Gastrointestinal mucormycosis. Gastrointest Radiol 1979;4:385-8.
8Thomson SR, Bade PG, Taams M, Chrystal V. Gastrointestinal mucormycosis. Br J Surg 1991;78:952-4.
9Baker RD, Linares G. Prednisolone induced mucormycosis in rhesus monkeys. J Med Vet Mycol 1974;12:75-80.

 
Wednesday, June 29, 2022
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