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Preimplantation diagnosis of genetic diseases
SK Adiga1, G Kalthur1, P Kumar1, KM Girisha2
1 Division of Reproductive Medicine, Kasturba Medical College, Manipal University, Manipal, India
2 Genetics Clinic, Kasturba Medical College, Manipal University, Manipal, India
Correspondence Address:
K M Girisha
Genetics Clinic, Kasturba Medical College, Manipal University, Manipal
India
One of the landmarks in clinical genetics is prenatal diagnosis of genetic disorders. The recent advances in the field have made it possible to diagnose the genetic conditions in the embryos before implantation in a setting of in vitro fertilization. Polymerase chain reaction and fluorescence in situ hybridization are the two common techniques employed on a single or two cells obtained via embryo biopsy. The couple who seek in vitro fertilization may screen their embryos for aneuploidy and the couple at risk for a monogenic disorder but averse to abortion of the affected fetuses after prenatal diagnosis, are likely to be the best candidates to undergo this procedure. This article reviews the technique, indications, benefits, and limitations of pre-implantation genetic testing in clinical practice.
How to cite this article:
Adiga S K, Kalthur G, Kumar P, Girisha K M. Preimplantation diagnosis of genetic diseases.J Postgrad Med 2010;56:317-320
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How to cite this URL:
Adiga S K, Kalthur G, Kumar P, Girisha K M. Preimplantation diagnosis of genetic diseases. J Postgrad Med [serial online] 2010 [cited 2023 Mar 20 ];56:317-320
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=2010;volume=56;issue=4;spage=317;epage=320;aulast=Adiga;type=0 |
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