Journal of Postgraduate Medicine
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CASE REPORT
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Year : 2013  |  Volume : 59  |  Issue : 2  |  Page : 135-137  

Diffusion weighted MR imaging of 5-fluorouracil and oxaliplatin-induced leukoencephalopathy

BS Paul1, G Singh1, R Bansal1, G Paul2 
1 Department of Neurology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
2 Intensive Care Unit, Dayanand Medical College and Hospital, Ludhiana, Punjab, India

Correspondence Address:
B S Paul
Department of Neurology, Dayanand Medical College and Hospital, Ludhiana, Punjab
India

A 55-year-old man treated with 5-fluorouracil and oxaliplatin for advanced sigmoid colon cancer presented with seizures, progressive gait and balance difficulties with frequent falls and slurring of speech. After three cycles of chemotherapy, brain magnetic resonance imaging using diffusion-weighted imaging clearly revealed the presence of high signal intensity in the deep white matter of the bilateral cerebral hemispheres, including the corpus callosum symmetrically. A diagnosis of acute leukoencephalopathy was made based on these findings. His clinical symptoms normalized after the discontinuation of the chemotherapy. Early detection of drug-induced leukoencephalopathy is important as the clinical symptoms can be reversed by early discontinuation of the causative drug. Diffusion-weighted magnetic resonance imaging is a useful modality for the early detection and definitive diagnosis of this characteristic encephalopathy.


How to cite this article:
Paul B S, Singh G, Bansal R, Paul G. Diffusion weighted MR imaging of 5-fluorouracil and oxaliplatin-induced leukoencephalopathy.J Postgrad Med 2013;59:135-137


How to cite this URL:
Paul B S, Singh G, Bansal R, Paul G. Diffusion weighted MR imaging of 5-fluorouracil and oxaliplatin-induced leukoencephalopathy. J Postgrad Med [serial online] 2013 [cited 2020 Dec 2 ];59:135-137
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=2013;volume=59;issue=2;spage=135;epage=137;aulast=Paul;type=0


 
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