S Kumar1, N Moorthy1, S Yadav2, A Kapoor1, DC Dale2,
1 Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
2 Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh
|How to cite this article:|
Kumar S, Moorthy N, Yadav S, Kapoor A, Dale D C. Authors' reply.J Postgrad Med 2013;59:340-341
|How to cite this URL:|
Kumar S, Moorthy N, Yadav S, Kapoor A, Dale D C. Authors' reply. J Postgrad Med [serial online] 2013 [cited 2021 Apr 18 ];59:340-341
Available from: https://www.jpgmonline.com/text.asp?2013/59/4/340/123188
We appreciate the letter addressing, the issues on diagnosis and management of thyroid storm in response to our article. , We agree that Burch and Wartofsky  have delineated a scoring system in an effort to standardize and objectify thyroid storm, as compared with severe thyrotoxicosis. Similarly, a thyroid storm diagnostic criteria has been proposed by Japan Thyroid Association (JTA).  However, it is important to consider thyroid storm in patients with severe thyrotoxicosis with critical illness and treat them aggressively, rather than focus on specific definitions.  Thyroid storm represents the extreme manifestation of thyrotoxicosis primarily judged by clinical manifestations, and as authors rightly pointed out, thyroid function tests do not help in differentiating between these two conditions. Similarly, radiological or nuclear imaging may or may not add any further information.  We agree that a multidrug approach using anti-thyroid drugs, iodine, beta-blockers, and glucocorticoids is usually required for the management of thyroid storm.  As our patient manifested with rapidly worsening congestive heart failure, aggressive management of heart failure with diuretics, beta-blocker, ACE inhibitor, and carbimazole resulted in dramatic improvement. Interestingly, our patient also had thrombosis at multiple locations, which is again not included under scoring system proposed by Burch and Wartofsky.  Our patient also did not have any neurological manifestations. Even though glucocorticoids are routinely used in the management of thyroid storm, we recommend glucocorticoids in cases not responding to routine measures. Since our patient was planned for radioiodine ablation, she was not given iodine.
We thus conclude that thyroid storm an endocrinal emergency is primarily diagnosed based on the clinical manifestations that requires early recognition and institution of treatment regardless of scoring systems.
|1||Kumar S, Moorthy N, Yadav S, Kapoor A, Dale DC. Thyroid storm presenting as congestive heart failure and protein-S deficiency-induced biventricular and internal jugular venous thrombii. J Postgrad Med 2013;59:229-31.|
|2||Chatterjee K, Sen C, Ghosh GC. Thyroid storm: An early clinical diagnosis and multidrug approach to therapy. J Postgrad Med 2013;59:339-40.|
|3||Burch HB, Wartofsky L. Life-threatening thyrotoxicosis. Thyroid storm. Endocrinol Metab Clin North Am 1993;22:263-77.|
|4||The Guideline Committee for Thyroid Storm of Japan Thyroid Association and Japan Endocrine Society (2008) Diagnostic criteria for thyroid storm, 1 st ed. Available from:http://thyroid.umin.ac.jp/rinsyo/crise1.pdf. (In Japanese). [Last accessed on 06/10/2013].|
|5||Nayak B, Burman K. Thyrotoxicosis and thyroid storm. Endocrinol Metab Clin North Am 2006;35:663-86, vii.|