Journal of Postgraduate Medicine
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LETTER
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Year : 2015  |  Volume : 61  |  Issue : 2  |  Page : 145  

Authors' reply

N Dominguez-Pinilla, M Baro-Fernandez, LI Gonzalez-Granado 
 Department of Pediatrics, Hematology and Oncology Unit, Hospital 12 Octubre, Madrid, Spain

Correspondence Address:
L I Gonzalez-Granado
Department of Pediatrics, Hematology and Oncology Unit, Hospital 12 Octubre, Madrid
Spain




How to cite this article:
Dominguez-Pinilla N, Baro-Fernandez M, Gonzalez-Granado L I. Authors' reply.J Postgrad Med 2015;61:145-145


How to cite this URL:
Dominguez-Pinilla N, Baro-Fernandez M, Gonzalez-Granado L I. Authors' reply. J Postgrad Med [serial online] 2015 [cited 2021 Apr 16 ];61:145-145
Available from: https://www.jpgmonline.com/text.asp?2015/61/2/145/153115


Full Text

Sir,

We thank Chhabra P for their comments. [1] The HIV test in our patient returned negative (HIV tests during pregnancy were also negative). It has also been reported HLH in AIDS is secondary not to the virus itself, but to overwhelming infections (particularly Pneumocystis jiroveci and nontuberculous mycobacteria). Complex immune mechanisms in HIV-Leishmania have been reported elsewhere. [2] In our country comparison between different microbiological techniques has been reported. However, serology is neither sensitive nor specific in the general Spanish population [3] and in HIV patients. [4] Our data on file in a pediatric cohort of HLH-Leishmania patients shows that only 32% of patients had a positive urine test. Thus, in our country the most reliable test remains PCR in bone marrow samples, followed by PCR in peripheral blood.

References

1Chhabra P. Offender: Virus or parasite or both. J Postgrad Med 2015;61:145.
2Okwor I1, Uzonna JE. The immunology of Leishmania/HIV co-infection. Immunol Res. 2013 May; 56:163-71.
3Cruz I1, Chicharro C, Nieto J, Bailo B, Cañavate C, Figueras MC. Comparison of new diagnostic tools for management of pediatric Mediterranean visceral leishmaniasis. J Clin Microbiol. 2006;44:2343-7.
4García-García JA, Martín-Sánchez J, Gállego M, Rivero-Román A, Camacho A, Riera C et al. Use of noninvasive markers to detect Leishmania infection in asymptomatic human immunodeficiency virus-infected patients. J Clin Microbiol. 200;44:4455-8.

 
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