Journal of Postgraduate Medicine
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CASE REPORT
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Year : 2021  |  Volume : 67  |  Issue : 4  |  Page : 238-240  

Transient congenital hypothyroidism – too short to be transient

K Subramaniam 
 Department of Endocrinology, Silverline Hospital, Kochi, Kerala, India

Correspondence Address:
K Subramaniam
Department of Endocrinology, Silverline Hospital, Kochi, Kerala
India

Congenital hypothyroidism (CH) occurs due to thyroid dysgenesis, thyroid ectopy, and dyshormonogenesis. A proportion of CH is transient which might be due to iodine deficiency/excess or maternal antibody-mediated. Certain forms of dyshormonogenetic defects may cause transient hypothyroidism. Here is a report of a neonate with overt clinical and biochemical hypothyroidism, who on evaluation was found to have dyshormonogenesis with a homozygous mutation in dual oxidase 2 (DUOX2) gene. During infancy, she became euthyroid. Severe in utero deficiency of thyroid hormone, very short duration of hypothyroidism and first-reported mutation of the DUOX2 gene in the Indian subcontinent were interesting features in this infant.


How to cite this article:
Subramaniam K. Transient congenital hypothyroidism – too short to be transient.J Postgrad Med 2021;67:238-240


How to cite this URL:
Subramaniam K. Transient congenital hypothyroidism – too short to be transient. J Postgrad Med [serial online] 2021 [cited 2022 Aug 12 ];67:238-240
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=2021;volume=67;issue=4;spage=238;epage=240;aulast=Subramaniam;type=0


 
Friday, August 12, 2022
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