Fifty patients undergoing open-heart surgery were studied. Twelve patients showed heparin rebound phenomenon in the post­perfusion period and was one of the important factors responsible for bleeding after open-heart surgery. The clotting time came back to normal in all the cases after administration of extra pro­tamine.

Foetomaternal haemorrhage is one of the important factors influencing maternal iso-immunization. In the present report at­tempt is made to study various aspects of foetomaternal haemor­rhage. While the overall incidence of foetal cell leak was observed in 21.43%, the incidence in the complicated deliveries ranged from. 27.94 to 85.72%. Incidence was not influenced by parity, however ABO compatible deliveries showed slight increase in the incidence (22.56%) as compared to ABO incompatible (18.75%) deliveries. ABO incompatible foetal cells were eliminated within 24 hours after delivery. Incidence of foetal cell leak was 8.28% in medical termination of pregnancy. Anth-Rh was produced in two out of nine women having foetal cell leak.

Wuchereria bancrofti microfilarial antigen was investigated in skin test on: (1) Microfilaria carriers, (2) Amicrofilaraemic cases from endemic villages with and without intestinal helminths, (3) Cases having apparent symptoms and signs of filariasis. The anti­gen reacted with specificity in cases having apparent symptoms and signs of filariasis. In microfilaria carriers and amicrofilaraemic individuals from endemic areas no reaction was seen. The diag­nostic value o f W. bancrofti microflarial antigen in chronic cases has been discussed.

Serum antibodies were studied in 187 cases of Urinary Tract Infection (UTI) divided into two groups. Group I consisted of 126 patients with 128 infections who had significant bacteriuria. 90 (70.3%) of these infections were associated with significant anti­body response (> 1:320) at the beginning of the study. It was further observed that uropathogens of all kinds were capable of producing antibody titre response. In the follow up study of 105 infections, it was noted that in 40.9% of infections inspite o f nega­tive urine culture, elevated antibody response persisted even after 3 months. In Group II, 61 patients with history of recurrent UTI with or without evidence of pyelonephritis were studied for re­sponses again` various serotypes of E. coli which were found to be common uropathogens. In this group too, majority o f the patients manifested elevated antibody response even when they had sterile urine at the time o f the study.

Infertility is a common problem and in about 40% of childless couples the husband may also need treatment, alone or alongwith the wife. ln India, however, not much attention has been paid to problems of male fertility and traditionally it is the wife who is primarily held at faith. A proper evaluation of every individual patient and exclusion of surgical conditions like varicocele or obstruction are necessary before starting any drug treatment. No stereotyped regime can succeed for each and every case. Andro­gens, gonadotropins, vitamins A & E, antibiotics and anti-inflam­matory agents are well established modes of therapy, but the dose­schedule has to be carefully determined. Some newer androgens (mesterolone and fIuoxymesterone) can be given orally and are very effective in directly stimulating spermatogenesis. Indigenous drugs (Speman) can be of considerable help in properly selected cases. The hypothalamic releasing factors (GH-RH), Bromocrip­tine etc. are still on trial but hold-promise for the future. Thyroid, anti-estrogens (Clomiphen), corticosteroids, arginine and vitamin B ₁₂ are of doubtful value only. Excessive smoking and alcohol ought to be discouraged. Since the beneficial effect of treatment could be only short lived, it is essential that the wife's fertility is simultaneously assured.

Present study deals with the immunoglobulin levels of the preterm and normal infants born of normal and infected mothers. Mean IgG in the full term infants (born of normal mothers) Was found to be 75% of the adult level. However mean IgG level was slightly higher in "small for date" babies than the preterm, but lower than the full term. IgM levels were comparable in all the three categories, whereas detectable IgA was found only in full term infants. A variable pattern was observed in the infants of all the three groups, born of infected mothers. There appeared to be a correlation of increased IgG with higher birth weight while lower birth weight infants had increased IgM.

A case-of Amoebic abscess of brain is presented and relevant Literature reviewed.

A case of leiomyoma of the duodenum which presented a diagnostic problem is reported. The literature regarding leiomnyoma of the duodenum is reviewed

A case of acrocephalosyndactyly diagnosed at birth is report­ed for its rarity. The typical features are described and the mode of inheritance discussed.

A case of fresh fish poisoning, most probably ciguatera, is reported. A brief review of the literature is presented.

A 72 year old male patient was admitted with complaints of dyspnoeaa of two months' duration. On local examination of 'he larynx, a polypoidal growth was seen in the sub glottis. Biopsy report was adenoid cystic carcinoma. Total laryngectomy was carried out. Post-operative course was uneventful. Occurrence of adenoid cystic carcinoma in the region of sub glottis is rare.

Pulmonary hypertension is uncommon in children with isolat­ed congenital aortic stenosis, and even when present is usually mild. It is primarily due to transmission of the elevated left ventricular end-diastolic pressure through the pulmonary capil­lary circulation and may be then further elevated by reflex vaso­constriction. In some cases the stretching of a patent foremen ovate secondary to elevated left atrial pressure; may lead to a significant left to right shunt which further enhances pulmonary hypertension. This report discusses two cases of isolated aortic stenosis developing pulmonary hypertension in childhood.