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  Citation statistics : Table of Contents
   2019| January-March  | Volume 65 | Issue 1  
    Online since January 28, 2019

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Polycystic ovary syndrome (PCOS) and kisspeptin – A Sri Lankan study
B Umayal, SN Jayakody, NV Chandrasekharan, W SS Wijesundera, CN Wijeyaratne
January-March 2019, 65(1):18-23
DOI:10.4103/jpgm.JPGM_683_17  PMID:30004037
Context: Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder affecting young women. Kisspeptins are a family of closely related peptides encoded by Kiss1 gene that controls the hypothalamic–pituitary–gonadal axis by binding to its receptor (GPR54) expressed in gonadotropin-releasing hormone (GnRH) neurons and releases GnRH. Since GnRH secretion is deregulated in PCOS, we hypothesized that dysregulated gonadotropin secretion in PCOS is reflected by kisspeptin levels. Aim: We aimed to measure serum kisspeptin levels of subjects with well-characterized PCOS versus controls and explore any correlation between kisspeptin and PCOS-related reproductive and metabolic disturbances. Materials and Methods: Consecutive women with PCOS manifesting from adolescence (n = 55) and adult controls (n = 110) were recruited. Pre-treatment baseline clinical, anthropometry, and biochemical parameters were measured in all. Serum kisspeptin and testosterone levels were determined by enzyme-linked immunosorbent assay method. Results: Serum kisspeptin and testosterone concentrations were significantly higher in women with PCOS (kisspeptin 4.873 nmol/L; testosterone 4.713 nmol/L) than controls (kisspeptin 4.127 nmol/L; testosterone 3.415 nmol/L; P < 0.05). Serum kisspeptin levels were positively associated with PCOS (odds ratio: 1.853; 95% confidence interval: 1.246–2.755; P = 0.002) in our studied population. Conclusion: Serum kisspeptin levels are higher in Sri Lankan women with PCOS manifesting from adolescence compared with controls regardless of body mass index. We propose serum kisspeptin concentration as a useful marker to recognize PCOS that manifests from adolescence.
  10 6,155 17
Access to hematopoietic stem-cell transplantation in India
U Kulkarni, B George
January-March 2019, 65(1):1-4
DOI:10.4103/jpgm.JPGM_391_18  PMID:30693869
  7 8,568 40
Unconditional probability of dying and age-specific mortality rate because of major non-communicable diseases in India: Time trends from 2001 to 2013
MM Reddy, SS Kar
January-March 2019, 65(1):11-17
DOI:10.4103/jpgm.JPGM_529_17  PMID:29943745
Background: Unconditional probability of dying because of four major non-communicable diseases (NCDs) between 30 and 70 years of age is the selected global indicator to measure the impact of NCD prevention and control programs. Objective: To calculate the unconditional probability of dying and age-specific mortality rate because of major NCDs in India from 2001 to 2013. Methods: This study used multiple data sources that are available in the public domain—Census 2001 and 2011, Sample Registration System, causes of death reports in 2001–03, 2004–06, and 2010–13. Unconditional probability of dying between ages 30 and 70 years during 2001, 2006, and 2013 was calculated by the formula suggested by the World Health Organization. Line graphs were used to depict time trends in age-specific mortality rates over the years in four major NCDs (cardiovascular diseases, cancer, diabetes, and chronic respiratory diseases). Results: The age-specific mortality rate because of four NCDs showed a decrease of 51 deaths per 100,000 population from 2001 to 2013. Of the four NCDs, age-specific mortality rate was highest in cardiovascular diseases (238.2/100,000 population) and least in diabetes mellitus (21.9/100,000 population); it was 76.3 and 58.2/100,000 population for cancer and chronic respiratory diseases, respectively. The probability of dying was very less and was almost the same from 30 to 44 years of life and increased steeply after that till 70 years of life; and it was more in males (24%) compared with females (17.4%). Conclusion: Although India has shown a decreasing trend in premature mortality because of NCDs in the past decade, the rate of decrease is not on par to achieve the global “25 × 25” target.
  6 7,439 17
Fungal fibrosing mediastinitis in pregnancy – Case report with review of literature
P Vaideeswar, J Chaudhari, N Goel
January-March 2019, 65(1):52-55
DOI:10.4103/jpgm.JPGM_358_18  PMID:30693874
Fibrosing mediastinitis (FM) is characterized by extensive and invasive fibro-inflammatory proliferation, triggered by a delayed hypersensitivity reaction to variety of infective or noninfective stimuli. The infective agents often have a geographic distribution such as Histoplasma capsulatum in North America and Mycobacterium tuberculosis in Asian regions. In few reports, the mediastinitis is caused by fungi, particularly Aspergillus species. We report the first case of possible aspergillous FM in a young pregnant woman.
  5 3,295 15
Noncommunicable diseases in India: Challenges and the way forward
A Banerjee
January-March 2019, 65(1):5-6
DOI:10.4103/jpgm.JPGM_157_18  PMID:30693870
  4 9,788 29
Rosai Dorfman disease and peripheral T-cell lymphoma: A rare co-occurrence
V Tiwari, A Pareek, H Ghori, M Ahirwar
January-March 2019, 65(1):62-63
DOI:10.4103/jpgm.JPGM_356_18  PMID:30464074
  3 3,013 16
An unusual cause of respiratory distress
S Rajagopala, N Selvam
January-March 2019, 65(1):38-40
DOI:10.4103/jpgm.JPGM_496_17  PMID:29943743
Exogenous lipoid pneumonia is a rare alveolar-filling disorder characterized by foreign body reaction to inhaled/aspirated hydrocarbon that may be vegetable oil, animal fat, or mineral oil. It is vanishingly rare and often missed except in the classical clinical settings of acute aspiration of petroleum products. We present a toddler with iatrogenic exogenous lipoid pneumonia and highlight clinical and radiological clues that can prompt early recognition of this entity.
  2 3,859 16
Synchronous renal cell carcinoma and pheochromocytoma presenting as acute decompensated heart failure
HH Chen, ST Wu, YC Lin, CS Lin
January-March 2019, 65(1):44-46
DOI:10.4103/jpgm.JPGM_701_17  PMID:30693873
We report a 49-year-old woman who presented with a hypertensive crisis and acute heart failure and reduced left ventricular systolic function. An abdominal ultrasonography revealed a huge lobulated heterogeneous mass at the lower pole of the right kidney and a mass over the left suprarenal area, which were further delineated by magnetic resonance imaging. The patient underwent laparoscopic right radical nephrectomy and left adrenalectomy. Histopathological analysis confirmed the diagnoses of clear cell renal cell carcinoma of the right kidney with metastasis to the lung; and atypical pheochromocytoma of the left adrenal gland. Target therapy was initiated, which resulted in stabilization of the patient's tumors and the recovery of her heart function. To avoid a delayed diagnosis and catastrophic outcome, clinicians should consider such rare causes of acute decompensated heart failure.
  2 4,348 16
Cabergoline treatment in prolactinoma: Amelioration in obstructive and central sleep apneas
M Binar, O Karakoc, C Haymana, H Arslan
January-March 2019, 65(1):47-49
DOI:10.4103/jpgm.JPGM_113_18  PMID:30147082
A 44-year-old male patient was admitted to the otolaryngology department with a history of progressive snoring, excessive daytime sleepiness, and reduced libido for the last 6 months. Polysomnography demonstrated the presence of moderate obstructive sleep apnea (OSA) with an apnea-hypopnea index (AHI) of 24.6 events/h, consisting of 77 obstructive and 59 central apneas. The marked number of central apneas in the sleep study and urologic complaints prompted the performance of brain magnetic resonance imaging (MRI), which indicated a pituitary macroadenoma (prolactinoma). Three months after treatment with cabergoline, a control MRI showed a significant reduction in the size of the macroadenoma. The AHI was also significantly decreased (to 11.6 events/h), as were the numbers of obstructive and central apneas. The patient's complaints regarding libido were also regressed. During this treatment period, CPAP therapy has not been tolerated by the patient. Cabergoline treatment reduced the severity of both obstructive and central sleep apneas in this patient.
  2 5,103 20
A prospective study of evaluation of operative duration as a predictor of mortality in pediatric emergency surgery: Concept of 100 minutes laparotomy in resource-limited setting
SM Kaushal-Deep, R Ahmad, M Lodhi, RS Chana
January-March 2019, 65(1):24-32
DOI:10.4103/jpgm.JPGM_52_18  PMID:30588925
Introduction: Operative duration is an important but under-studied predictor of mortality in emergency laparotomies. Aims and Objectives: The primary objective of this study was to quantify the effect of duration of emergency laparotomy in children on mortality; and to identify a rough cut-off duration of laparotomy to serve as a guide so that a laparotomy can be planned to optimize pediatric surgical patient outcome. Materials and Methods: This is a prospective study conducted in a government tertiary teaching institution over a period of 24 months. All children in the age group of 5–10 years presenting in the emergency department with Pediatric Risk of Mortality III score ≤8, undergoing emergency laparotomy in emergency operation theater, were included. Observations and Results: In all, 213 children were included in the study. The mean time from presentation to shifting to the operating room was 3.7 h. The mean operative duration was 108 min. The mean operative time in survived patients was 102 min as compared to 135 min in expired patients (P < 0.05). The 30-day in-hospital mortality rate was 17.4%. After application of binary logistic regression analysis, it was found that time to laparotomy and operative duration were significant risk factors (<0.05) predicting post-operative mortality. Kaplan–Meier survival curve showed a decrease at a mean weighted operative duration of approximately 100 min. Receiver operating characteristic curve analysis yielded operative duration of 123.5 min at which Youden's index maximized. Conclusion: This 100-min duration of laparotomy might appear a long duration but in casualty setup of a government hospital with limited resources, there are so many hurdles for optimal working that completion of an emergency laparotomy in children in 100 min can be considered a realistic target for improving post-operative outcome. At an operative duration of <123.50 min, mortality rates within acceptable limits can be achieved.
  2 3,221 16
Brain SPECT scans in students with specific learning disability: Preliminary results
S Karande, N Deshmukh, V Rangarajan, A Agrawal, R Sholapurwala
January-March 2019, 65(1):33-37
DOI:10.4103/jpgm.JPGM_61_18  PMID:29882521
Background and Objectives: Brain single-photon emission computed tomography (SPECT) assesses brain function through measurement of regional cerebral blood flow. This study was conducted to assess whether students with newly diagnosed specific learning disability (SpLD) show any abnormalities in cerebral cortex perfusion. Settings and Design: Cross-sectional single-arm pilot study in two tertiary care hospitals. Subjects and Methods: Nine students with SpLD were enrolled. Brain SPECT scan was done twice in each student. For the first or “baseline" scan, the student was first made to sit with eyes open in a quiet, dimly lit room for a period of 30–40 min and then injected intravenously with 20 mCi of 99mTc-ECD. An hour later, “baseline scan" was conducted. After a minimum gap of 4 days, a second or “test scan" was conducted, wherein the student performed an age-appropriate curriculum-based test for a period of 30–40 min to activate the areas in central nervous system related to learning before being injected with 20 mCi of 99mTc-ECD. Statistical Analysis Used: Cerebral cortex perfusion at rest and after activation in each student was compared qualitatively by visual analysis and quantitatively using NeuroGam™ software. Results: Visual analysis showed reduction in regional blood flow in temporoparietal areas in both “baseline" and “test" scans. However, when normalization was attempted and comparison done by Talairach analysis using NeuroGam software, no statistically significant change in regional perfusion in temporoparietal areas was appreciated. Conclusion: Brain SPECT scan may serve as a robust tool to identify changes in regional brain perfusion in students with SpLD.
  1 6,007 20
Emphysematous osteomyelitis caused by Salmonella typhi in beta thalassemia major
PN Doctor, M Verma, A Varaiya, RH Merchant
January-March 2019, 65(1):41-43
DOI:10.4103/jpgm.JPGM_689_17  PMID:29882519
There have been various cases of salmonella osteomyelitis reported in sickle cell anemia. We present a case of emphysematous osteomyelitis caused by Salmonella typhi in a 29-year-old beta thalassemia major patient. Diagnosis of emphysematous osteomyelitis was confirmed by computed tomography and magnetic resonance imaging, and culture of pus drained during surgical debridement confirmed the causative microorganism, Salmonella typhi. Antimicrobials were given according to microbiological sensitivity for a period of 8 weeks. Our patient also received hyperbaric oxygen therapy. At the end of therapy, he was afebrile and laboratory parameters normalized with a residual joint deformity which developed within 3 months.
  1 5,275 16
A rare complication of cardiac surgery: Ogilvie syndrome
DV Garbuzenko, DV Belov, NO Arefyev
January-March 2019, 65(1):56-57
DOI:10.4103/jpgm.JPGM_405_18  PMID:30693875
  1 2,934 17
Isolated intraluminal ureteral endometriosis mimicking tuberculosis
S Rajaian, M Pragatheeswarane, K Krishnamurthy, SC Narasimhachar
January-March 2019, 65(1):58-59
DOI:10.4103/jpgm.JPGM_458_18  PMID:30693876
  1 2,912 15
Linear focal elastosis localized to bilateral knee of a marathon runner
I Kaur, D Jakhar, SN Bhattacharya, S Sharma
January-March 2019, 65(1):60-61
DOI:10.4103/jpgm.JPGM_494_18  PMID:30693877
  1 2,945 15
Acute hemichorea revealing atrial flutter
B Hebant, L Guyant-Marechal, D Maltête, R Lefaucheur
January-March 2019, 65(1):50-51
DOI:10.4103/jpgm.JPGM_448_18  PMID:30588926
Transient ischemic attacks (TIAs) typically present with easily recognizable neurological focal deficits. Symptoms such as paroxysmal involuntary movements are not usually considered to be a manifestation of TIA. We report a case with video documentation of TIA due to permanent atrial flutter presenting as acute left hemichorea. To our knowledge, such a case has not yet been reported. The present case constitutes a crucial diagnostic challenge in neurological practice in order to prevent a high risk of subsequent ischemic stroke.
  - 3,216 16
Time duration of an emergency pediatric laparotomy can impact its outcome
P Kothari
January-March 2019, 65(1):7-8
DOI:10.4103/jpgm.JPGM_240_18  PMID:30693871
  - 3,920 67
Brain SPECT scans: A promising research tool for specific learning disability
Z Meng, D Sun
January-March 2019, 65(1):9-10
DOI:10.4103/jpgm.JPGM_309_18  PMID:30693872
  - 2,920 16
Listerial meningitis: A diagnostic dilemma
S Jain, S Otta, B Swain, S Sahoo
January-March 2019, 65(1):64-65
DOI:10.4103/jpgm.JPGM_431_18  PMID:30693878
  - 3,871 15
Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow